2Q7R
Crystal structure of human FLAP with an iodinated analog of MK-591
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Arachidonate 5-lipoxygenase-activating protein | polymer | 161 | 18252.6 | 6 | UniProt (P20292) Pfam (PF01124) | Homo sapiens (human) | FLAP, MK-886-binding protein |
| 2 | G, H, I, J, K... (A, B, C, D, E...) | 3-[3-(3,3-DIMETHYLBUTANOYL)-1-(4-IODOBENZYL)-5-(QUINOLIN-2-YLMETHOXY)-1H-INDOL-2-YL]-2,2-DIMETHYLPROPANOIC ACID | non-polymer | 688.6 | 6 | Chemie (3CS) |
Sequence modifications
A, B, C, D, E, F: 1 - 161 (UniProt: P20292)
| PDB | External Database | Details |
|---|---|---|
| Mse 1 | Met 1 | modified residue |
| Mse 89 | Met 89 | modified residue |
| Mse 125 | Met 125 | modified residue |
| Ala 148 | Lys 148 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 109515.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 4131.6 | |
| All* | Total formula weight | 113647.1 |
