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2Q7R

Crystal structure of human FLAP with an iodinated analog of MK-591

Functional Information from GO Data
ChainGOidnamespacecontents
A0002540biological_processleukotriene production involved in inflammatory response
A0002675biological_processpositive regulation of acute inflammatory response
A0004051molecular_functionarachidonate 5-lipoxygenase activity
A0004364molecular_functionglutathione transferase activity
A0004464molecular_functionleukotriene-C4 synthase activity
A0004602molecular_functionglutathione peroxidase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0006691biological_processleukotriene metabolic process
A0008047molecular_functionenzyme activator activity
A0016020cellular_componentmembrane
A0019370biological_processleukotriene biosynthetic process
A0019372biological_processlipoxygenase pathway
A0019899molecular_functionenzyme binding
A0031965cellular_componentnuclear membrane
A0042802molecular_functionidentical protein binding
A0044877molecular_functionprotein-containing complex binding
A0050544molecular_functionarachidonic acid binding
A0070207biological_processprotein homotrimerization
A0071277biological_processcellular response to calcium ion
A0098869biological_processcellular oxidant detoxification
B0002540biological_processleukotriene production involved in inflammatory response
B0002675biological_processpositive regulation of acute inflammatory response
B0004051molecular_functionarachidonate 5-lipoxygenase activity
B0004364molecular_functionglutathione transferase activity
B0004464molecular_functionleukotriene-C4 synthase activity
B0004602molecular_functionglutathione peroxidase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0006691biological_processleukotriene metabolic process
B0008047molecular_functionenzyme activator activity
B0016020cellular_componentmembrane
B0019370biological_processleukotriene biosynthetic process
B0019372biological_processlipoxygenase pathway
B0019899molecular_functionenzyme binding
B0031965cellular_componentnuclear membrane
B0042802molecular_functionidentical protein binding
B0044877molecular_functionprotein-containing complex binding
B0050544molecular_functionarachidonic acid binding
B0070207biological_processprotein homotrimerization
B0071277biological_processcellular response to calcium ion
B0098869biological_processcellular oxidant detoxification
C0002540biological_processleukotriene production involved in inflammatory response
C0002675biological_processpositive regulation of acute inflammatory response
C0004051molecular_functionarachidonate 5-lipoxygenase activity
C0004364molecular_functionglutathione transferase activity
C0004464molecular_functionleukotriene-C4 synthase activity
C0004602molecular_functionglutathione peroxidase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005635cellular_componentnuclear envelope
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0006691biological_processleukotriene metabolic process
C0008047molecular_functionenzyme activator activity
C0016020cellular_componentmembrane
C0019370biological_processleukotriene biosynthetic process
C0019372biological_processlipoxygenase pathway
C0019899molecular_functionenzyme binding
C0031965cellular_componentnuclear membrane
C0042802molecular_functionidentical protein binding
C0044877molecular_functionprotein-containing complex binding
C0050544molecular_functionarachidonic acid binding
C0070207biological_processprotein homotrimerization
C0071277biological_processcellular response to calcium ion
C0098869biological_processcellular oxidant detoxification
D0002540biological_processleukotriene production involved in inflammatory response
D0002675biological_processpositive regulation of acute inflammatory response
D0004051molecular_functionarachidonate 5-lipoxygenase activity
D0004364molecular_functionglutathione transferase activity
D0004464molecular_functionleukotriene-C4 synthase activity
D0004602molecular_functionglutathione peroxidase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005635cellular_componentnuclear envelope
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0006691biological_processleukotriene metabolic process
D0008047molecular_functionenzyme activator activity
D0016020cellular_componentmembrane
D0019370biological_processleukotriene biosynthetic process
D0019372biological_processlipoxygenase pathway
D0019899molecular_functionenzyme binding
D0031965cellular_componentnuclear membrane
D0042802molecular_functionidentical protein binding
D0044877molecular_functionprotein-containing complex binding
D0050544molecular_functionarachidonic acid binding
D0070207biological_processprotein homotrimerization
D0071277biological_processcellular response to calcium ion
D0098869biological_processcellular oxidant detoxification
E0002540biological_processleukotriene production involved in inflammatory response
E0002675biological_processpositive regulation of acute inflammatory response
E0004051molecular_functionarachidonate 5-lipoxygenase activity
E0004364molecular_functionglutathione transferase activity
E0004464molecular_functionleukotriene-C4 synthase activity
E0004602molecular_functionglutathione peroxidase activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005635cellular_componentnuclear envelope
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0006691biological_processleukotriene metabolic process
E0008047molecular_functionenzyme activator activity
E0016020cellular_componentmembrane
E0019370biological_processleukotriene biosynthetic process
E0019372biological_processlipoxygenase pathway
E0019899molecular_functionenzyme binding
E0031965cellular_componentnuclear membrane
E0042802molecular_functionidentical protein binding
E0044877molecular_functionprotein-containing complex binding
E0050544molecular_functionarachidonic acid binding
E0070207biological_processprotein homotrimerization
E0071277biological_processcellular response to calcium ion
E0098869biological_processcellular oxidant detoxification
F0002540biological_processleukotriene production involved in inflammatory response
F0002675biological_processpositive regulation of acute inflammatory response
F0004051molecular_functionarachidonate 5-lipoxygenase activity
F0004364molecular_functionglutathione transferase activity
F0004464molecular_functionleukotriene-C4 synthase activity
F0004602molecular_functionglutathione peroxidase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005635cellular_componentnuclear envelope
F0005783cellular_componentendoplasmic reticulum
F0005789cellular_componentendoplasmic reticulum membrane
F0006691biological_processleukotriene metabolic process
F0008047molecular_functionenzyme activator activity
F0016020cellular_componentmembrane
F0019370biological_processleukotriene biosynthetic process
F0019372biological_processlipoxygenase pathway
F0019899molecular_functionenzyme binding
F0031965cellular_componentnuclear membrane
F0042802molecular_functionidentical protein binding
F0044877molecular_functionprotein-containing complex binding
F0050544molecular_functionarachidonic acid binding
F0070207biological_processprotein homotrimerization
F0071277biological_processcellular response to calcium ion
F0098869biological_processcellular oxidant detoxification
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 3CS C 501
ChainResidue
AVAL21
CILE119
CLEU120
CPHE123
AASN23
AGLY24
APHE25
AALA27
CASP62
CTHR66
CILE113
CPHE114

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 3CS B 502
ChainResidue
BASP62
BALA63
BPHE114
BLYS116
BILE119
BLEU120
BPHE123
CVAL21
CASN23
CGLY24
CPHE25
CALA27

site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 3CS A 503
ChainResidue
AASP62
ALYS116
AILE119
ALEU120
APHE123
BVAL21
BASN23
BGLY24
BPHE25
BALA27
BHIS28

site_idAC4
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 3CS F 504
ChainResidue
DVAL21
DASN23
DGLY24
DPHE25
DALA27
FASP62
FALA63
FPHE114
FLYS116
FILE119
FLEU120
FPHE123

site_idAC5
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 3CS D 505
ChainResidue
DASP62
DALA63
DTHR66
DILE113
DLYS116
DILE119
DLEU120
DPHE123
EVAL21
EASN23
EGLY24
EPHE25
EALA27

site_idAC6
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 3CS E 506
ChainResidue
EASP62
ETYR112
ELYS116
EILE119
ELEU120
EPHE123
FVAL21
FASN23
FGLY24
FPHE25
FALA27
FHIS28

Functional Information from PROSITE/UniProt
site_idPS01297
Number of Residues15
DetailsFLAP_GST2_LTC4S FLAP/GST2/LTC4S family signature. GtlaFERVYtANqNC
ChainResidueDetails
AGLY46-CYS60

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues246
DetailsTOPO_DOM: Lumenal => ECO:0000269|PubMed:17600184
ChainResidueDetails
AMSE1-ASN8
DMSE1-ASN8
DCYS78-GLN80
DGLY129-PRO161
EMSE1-ASN8
ECYS78-GLN80
EGLY129-PRO161
FMSE1-ASN8
FCYS78-GLN80
FGLY129-PRO161
ACYS78-GLN80
AGLY129-PRO161
BMSE1-ASN8
BCYS78-GLN80
BGLY129-PRO161
CMSE1-ASN8
CCYS78-GLN80
CGLY129-PRO161

site_idSWS_FT_FI2
Number of Residues468
DetailsTRANSMEM: Helical
ChainResidueDetails
AVAL9-VAL30
CVAL53-LEU77
CVAL81-LEU102
CLYS116-ALA128
DVAL9-VAL30
DVAL53-LEU77
DVAL81-LEU102
DLYS116-ALA128
EVAL9-VAL30
EVAL53-LEU77
EVAL81-LEU102
AVAL53-LEU77
ELYS116-ALA128
FVAL9-VAL30
FVAL53-LEU77
FVAL81-LEU102
FLYS116-ALA128
AVAL81-LEU102
ALYS116-ALA128
BVAL9-VAL30
BVAL53-LEU77
BVAL81-LEU102
BLYS116-ALA128
CVAL9-VAL30

site_idSWS_FT_FI3
Number of Residues150
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:17600184
ChainResidueDetails
AGLU31-ARG52
EGLY103-GLN107
FGLU31-ARG52
FGLY103-GLN107
AGLY103-GLN107
BGLU31-ARG52
BGLY103-GLN107
CGLU31-ARG52
CGLY103-GLN107
DGLU31-ARG52
DGLY103-GLN107
EGLU31-ARG52

site_idSWS_FT_FI4
Number of Residues42
DetailsINTRAMEM:
ChainResidueDetails
ASER108-GLY115
BSER108-GLY115
CSER108-GLY115
DSER108-GLY115
ESER108-GLY115
FSER108-GLY115

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PDB entries from 2024-05-01

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