Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2Q7R

Crystal structure of human FLAP with an iodinated analog of MK-591

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002540	biological_process	leukotriene production involved in inflammatory response
A	0004364	molecular_function	glutathione transferase activity
A	0004464	molecular_function	leukotriene-C4 synthase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006691	biological_process	leukotriene metabolic process
A	0008047	molecular_function	enzyme activator activity
A	0016020	cellular_component	membrane
A	0019370	biological_process	leukotriene biosynthetic process
A	0031965	cellular_component	nuclear membrane
A	0046394	biological_process	carboxylic acid biosynthetic process
A	0050544	molecular_function	arachidonate binding
A	0070207	biological_process	protein homotrimerization
A	0071277	biological_process	cellular response to calcium ion
A	0098869	biological_process	cellular oxidant detoxification
B	0002540	biological_process	leukotriene production involved in inflammatory response
B	0004364	molecular_function	glutathione transferase activity
B	0004464	molecular_function	leukotriene-C4 synthase activity
B	0004602	molecular_function	glutathione peroxidase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006691	biological_process	leukotriene metabolic process
B	0008047	molecular_function	enzyme activator activity
B	0016020	cellular_component	membrane
B	0019370	biological_process	leukotriene biosynthetic process
B	0031965	cellular_component	nuclear membrane
B	0046394	biological_process	carboxylic acid biosynthetic process
B	0050544	molecular_function	arachidonate binding
B	0070207	biological_process	protein homotrimerization
B	0071277	biological_process	cellular response to calcium ion
B	0098869	biological_process	cellular oxidant detoxification
C	0002540	biological_process	leukotriene production involved in inflammatory response
C	0004364	molecular_function	glutathione transferase activity
C	0004464	molecular_function	leukotriene-C4 synthase activity
C	0004602	molecular_function	glutathione peroxidase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006691	biological_process	leukotriene metabolic process
C	0008047	molecular_function	enzyme activator activity
C	0016020	cellular_component	membrane
C	0019370	biological_process	leukotriene biosynthetic process
C	0031965	cellular_component	nuclear membrane
C	0046394	biological_process	carboxylic acid biosynthetic process
C	0050544	molecular_function	arachidonate binding
C	0070207	biological_process	protein homotrimerization
C	0071277	biological_process	cellular response to calcium ion
C	0098869	biological_process	cellular oxidant detoxification
D	0002540	biological_process	leukotriene production involved in inflammatory response
D	0004364	molecular_function	glutathione transferase activity
D	0004464	molecular_function	leukotriene-C4 synthase activity
D	0004602	molecular_function	glutathione peroxidase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005635	cellular_component	nuclear envelope
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006691	biological_process	leukotriene metabolic process
D	0008047	molecular_function	enzyme activator activity
D	0016020	cellular_component	membrane
D	0019370	biological_process	leukotriene biosynthetic process
D	0031965	cellular_component	nuclear membrane
D	0046394	biological_process	carboxylic acid biosynthetic process
D	0050544	molecular_function	arachidonate binding
D	0070207	biological_process	protein homotrimerization
D	0071277	biological_process	cellular response to calcium ion
D	0098869	biological_process	cellular oxidant detoxification
E	0002540	biological_process	leukotriene production involved in inflammatory response
E	0004364	molecular_function	glutathione transferase activity
E	0004464	molecular_function	leukotriene-C4 synthase activity
E	0004602	molecular_function	glutathione peroxidase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005635	cellular_component	nuclear envelope
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0006691	biological_process	leukotriene metabolic process
E	0008047	molecular_function	enzyme activator activity
E	0016020	cellular_component	membrane
E	0019370	biological_process	leukotriene biosynthetic process
E	0031965	cellular_component	nuclear membrane
E	0046394	biological_process	carboxylic acid biosynthetic process
E	0050544	molecular_function	arachidonate binding
E	0070207	biological_process	protein homotrimerization
E	0071277	biological_process	cellular response to calcium ion
E	0098869	biological_process	cellular oxidant detoxification
F	0002540	biological_process	leukotriene production involved in inflammatory response
F	0004364	molecular_function	glutathione transferase activity
F	0004464	molecular_function	leukotriene-C4 synthase activity
F	0004602	molecular_function	glutathione peroxidase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005635	cellular_component	nuclear envelope
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0006691	biological_process	leukotriene metabolic process
F	0008047	molecular_function	enzyme activator activity
F	0016020	cellular_component	membrane
F	0019370	biological_process	leukotriene biosynthetic process
F	0031965	cellular_component	nuclear membrane
F	0046394	biological_process	carboxylic acid biosynthetic process
F	0050544	molecular_function	arachidonate binding
F	0070207	biological_process	protein homotrimerization
F	0071277	biological_process	cellular response to calcium ion
F	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3CS C 501

Chain	Residue
A	VAL21
C	ILE119
C	LEU120
C	PHE123
A	ASN23
A	GLY24
A	PHE25
A	ALA27
C	ASP62
C	THR66
C	ILE113
C	PHE114

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3CS B 502

Chain	Residue
B	ASP62
B	ALA63
B	PHE114
B	LYS116
B	ILE119
B	LEU120
B	PHE123
C	VAL21
C	ASN23
C	GLY24
C	PHE25
C	ALA27

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 3CS A 503

Chain	Residue
A	ASP62
A	LYS116
A	ILE119
A	LEU120
A	PHE123
B	VAL21
B	ASN23
B	GLY24
B	PHE25
B	ALA27
B	HIS28

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3CS F 504

Chain	Residue
D	VAL21
D	ASN23
D	GLY24
D	PHE25
D	ALA27
F	ASP62
F	ALA63
F	PHE114
F	LYS116
F	ILE119
F	LEU120
F	PHE123

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 3CS D 505

Chain	Residue
D	ASP62
D	ALA63
D	THR66
D	ILE113
D	LYS116
D	ILE119
D	LEU120
D	PHE123
E	VAL21
E	ASN23
E	GLY24
E	PHE25
E	ALA27

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3CS E 506

Chain	Residue
E	ASP62
E	TYR112
E	LYS116
E	ILE119
E	LEU120
E	PHE123
F	VAL21
F	ASN23
F	GLY24
F	PHE25
F	ALA27
F	HIS28

Functional Information from PROSITE/UniProt

site_id	PS01297
Number of Residues	15
Details	FLAP_GST2_LTC4S FLAP/GST2/LTC4S family signature. GtlaFERVYtANqNC

Chain	Residue	Details
A	GLY46-CYS60

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	270
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	150
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"17600184","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"17600184","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	42
Details	Intramembrane: {}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)