2Q59

Crystal Structure of PPARgamma LBD bound to full agonist MRL20

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Peroxisome Proliferator-Activated Receptor gamma	polymer	274	31371.4	1	UniProt (P37231) Pfam (PF00104)	Homo sapiens (human)	PPAR-gamma
2	B (B)	Peroxisome Proliferator-Activated Receptor gamma	polymer	274	31295.3	1	UniProt (P37231) Pfam (PF00104)	Homo sapiens (human)	PPAR-gamma
3	C, D (A, B)	(2S)-2-(2-{[1-(4-METHOXYBENZOYL)-2-METHYL-5-(TRIFLUOROMETHOXY)-1H-INDOL-3-YL]METHYL}PHENOXY)PROPANOIC ACID	non-polymer		527.5	2	Chemie (240)
4	E, F (A, B)	water	water		18.0	244	Chemie (HOH)

Sequence modifications

A: 205 - 477 (UniProt: P37231)

PDB	External Database	Details
Ser 204	-	expression tag
Cme 285	Cys 313	modified residue

B: 205 - 477 (UniProt: P37231)

PDB	External Database	Details
Ser 204	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	62666.7
Non-Polymers*	Number of molecules	2
	Total formula weight	1055.0
All*	Total formula weight	63721.7

*Water molecules are not included.