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2Q59

Crystal Structure of PPARgamma LBD bound to full agonist MRL20

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 240 A 5001
ChainResidue
ACME285
ALEU333
AVAL339
ALEU340
ALEU353
AHIS449
ATYR473
AARG288
ASER289
AALA292
AILE296
AHIS323
ATYR327
AMET329
ALEU330

site_idAC2
Number of Residues17
DetailsBINDING SITE FOR RESIDUE 240 B 7001
ChainResidue
BPHE282
BCYS285
BGLN286
BARG288
BSER289
BALA292
BILE296
BILE326
BMET329
BLEU330
BLEU333
BVAL339
BILE341
BMET348
BMET364
BLYS367
BHIS449

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
ChainResidueDetails
BTYR473
BGLN286
BHIS323
BHIS449

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
ChainResidueDetails
BLYS224

221051

PDB entries from 2024-06-12

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