2PZG
Minimal human CFTR first nucleotide binding domain as a monomer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cystic fibrosis transmembrane conductance regulator | polymer | 241 | 27066.1 | 2 | UniProt (P13569) Pfam (PF00005) | Homo sapiens (human) | CFTR, cAMP- dependent chloride channel, ATP-binding cassette transporter sub- family C member 7 |
| 2 | C, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, G (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 4 | E, H, I (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 250 | Chemie (HOH) |
Sequence modifications
A, B: 375 - 404 (UniProt: P13569)
A, B: 437 - 646 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| Ser 374 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 470 | Val 470 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54132.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1339.3 | |
| All* | Total formula weight | 55471.5 |
