2PZG

Minimal human CFTR first nucleotide binding domain as a monomer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
B	0005524	molecular_function	ATP binding
B	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 3

Chain	Residue
A	ATP1
A	THR465
A	GLN493
A	HOH647
A	HOH648

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 4

Chain	Residue
B	HOH648
B	ATP2
B	THR465
B	GLN493
B	HOH647

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ATP A 1

Chain	Residue
A	MG3
A	TRP401
A	VAL440
A	THR460
A	GLY461
A	ALA462
A	GLY463
A	LYS464
A	THR465
A	SER466
A	GLN493
A	HOH647
A	HOH648
A	HOH667
A	HOH692
A	HOH754
A	HOH765

---

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ATP B 2

Chain	Residue
B	MG4
B	TRP401
B	VAL440
B	THR460
B	GLY461
B	ALA462
B	GLY463
B	LYS464
B	THR465
B	SER466
B	GLN493
B	HOH647
B	HOH648
B	HOH674
B	HOH737
B	HOH740
B	HOH751
B	HOH757
B	HOH767

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 5

Chain	Residue
B	TYR577
B	TYR627
B	HOH655
B	HOH770

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 6

Chain	Residue
A	GLY551
A	GLN552
A	ARG555
A	LEU578
A	ASP579
A	HOH702
A	HOH715

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 7

Chain	Residue
B	SER489
B	TRP496
B	PHE508
B	ARG560
B	LYS564
B	HOH651
B	HOH659
B	HOH697

---

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRARISLARAV

Chain	Residue	Details
A	LEU548-VAL562

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15528182","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20150177","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PZE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PZF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PZG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15528182","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15528182","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"22119790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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