2PZD
Crystal Structure of the HtrA2/Omi PDZ Domain Bound to a Phage-Derived Ligand (WTMFWV)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine protease HTRA2 | polymer | 113 | 12593.5 | 2 | UniProt (O43464) Pfam (PF17820) | Homo sapiens (human) | High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine proteinase OMI, Serine protease 25 |
| 2 | C, D (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence modifications
A, B: 359 - 458 (UniProt: O43464)
| PDB | External Database | Details |
|---|---|---|
| Gly 355 | - | cloning artifact |
| Ser 356 | - | cloning artifact |
| His 357 | - | cloning artifact |
| Met 358 | - | cloning artifact |
| Gly 459 | - | linker |
| Gly 460 | - | linker |
| Gly 461 | - | linker |
| Trp 462 | - | SEE REMARK 999 |
| Thr 463 | - | SEE REMARK 999 |
| Met 464 | - | SEE REMARK 999 |
| Phe 465 | - | SEE REMARK 999 |
| Trp 466 | - | SEE REMARK 999 |
| Val 467 | - | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 25187.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 124.1 | |
| All* | Total formula weight | 25311.2 |
