2PX8
Crystal structure of the Murray Valley Encephalitis Virus NS5 2'-O Methyltransferase domain in complex with SAH and 7M-GTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)] | polymer | 269 | 30415.0 | 2 | UniProt (P05769) Pfam (PF01728) | Murray valley encephalitis virus (strain MVE-1-51) | |
| 2 | C, H, I (A, B) | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 539.2 | 3 | Chemie (MGT) | |||
| 3 | D, J (A, B) | TRIPHOSPHATE | non-polymer | 258.0 | 2 | Chemie (3PO) | |||
| 4 | E, K (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 5 | F, L (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | G (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | M, N (A, B) | water | water | 18.0 | 427 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 269 (UniProt: P05769)
| PDB | External Database | Details |
|---|---|---|
| Mly 15 | Lys 2544 | modified residue |
| Mly 76 | Lys 2605 | modified residue |
| Mly 95 | Lys 2624 | modified residue |
| Mly 105 | Lys 2634 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 60830.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3122.0 | |
| All* | Total formula weight | 63952.1 |
