Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| A | 0004483 | molecular_function | methyltransferase cap1 activity |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| B | 0004483 | molecular_function | methyltransferase cap1 activity |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 502 |
| Chain | Residue |
| B | ASN17 |
| B | TYR119 |
| B | ALA266 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE MGT A 401 |
| Chain | Residue |
| A | MLY95 |
| A | ASN96 |
| A | SER150 |
| A | SER151 |
| A | PRO152 |
| A | ARG213 |
| A | SER215 |
| A | GOL463 |
| A | HOH679 |
| A | HOH725 |
| A | HOH750 |
| A | HOH759 |
| A | LYS13 |
| A | LEU16 |
| A | ASN17 |
| A | MET19 |
| A | PHE24 |
| A | ARG28 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE MGT B 402 |
| Chain | Residue |
| B | LYS13 |
| B | LEU16 |
| B | ASN17 |
| B | MET19 |
| B | LYS21 |
| B | PHE24 |
| B | ARG28 |
| B | MLY95 |
| B | ASN96 |
| B | SER150 |
| B | SER151 |
| B | PRO152 |
| B | ARG213 |
| B | SER215 |
| B | ASN216 |
| B | GOL468 |
| B | HOH532 |
| B | HOH672 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MGT B 403 |
| Chain | Residue |
| A | SER197 |
| A | ARG201 |
| B | GLU22 |
| B | PHE25 |
| B | HOH729 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 3PO A 451 |
| Chain | Residue |
| A | ARG37 |
| A | ARG41 |
| A | VAL55 |
| A | SER56 |
| A | ARG57 |
| A | ARG84 |
| A | HOH682 |
| A | HOH921 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 3PO B 452 |
| Chain | Residue |
| B | ARG37 |
| B | ARG41 |
| B | VAL55 |
| B | SER56 |
| B | ARG57 |
| B | ARG84 |
| B | HOH844 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SAH A 500 |
| Chain | Residue |
| A | SER56 |
| A | GLY58 |
| A | GLY81 |
| A | CYS82 |
| A | GLY83 |
| A | GLY86 |
| A | TRP87 |
| A | MLY105 |
| A | HIS110 |
| A | GLU111 |
| A | VAL130 |
| A | ASP131 |
| A | VAL132 |
| A | PHE133 |
| A | ASP146 |
| A | HOH503 |
| A | HOH505 |
| A | HOH556 |
| A | HOH746 |
| site_id | AC8 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE SAH B 500 |
| Chain | Residue |
| B | SER56 |
| B | GLY58 |
| B | GLY81 |
| B | CYS82 |
| B | GLY83 |
| B | GLY86 |
| B | TRP87 |
| B | MLY105 |
| B | HIS110 |
| B | GLU111 |
| B | VAL130 |
| B | ASP131 |
| B | VAL132 |
| B | PHE133 |
| B | ASP146 |
| B | ILE147 |
| B | GLU149 |
| B | HOH510 |
| B | HOH512 |
| B | HOH516 |
| B | HOH619 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 463 |
| Chain | Residue |
| A | ASN17 |
| A | MLY95 |
| A | PRO152 |
| A | ARG265 |
| A | MGT401 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL B 468 |
| Chain | Residue |
| B | ASN17 |
| B | MLY95 |
| B | VAL97 |
| B | GLN98 |
| B | ARG265 |
| B | ALA266 |
| B | VAL267 |
| B | GLY268 |
| B | MGT402 |
| B | HOH513 |
| B | HOH672 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"description":"For 2'-O-MTase activity","evidences":[{"source":"UniProtKB","id":"Q6YMS4","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Site: {"description":"mRNA cap binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"mRNA cap binding; via carbonyl oxygen","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Site: {"description":"Essential for 2'-O-methyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Essential for 2'-O-methyltransferase and N-7 methyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P03314","evidenceCode":"ECO:0000250"}]} |
