2PX6
Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Thioesterase domain | polymer | 316 | 34731.2 | 2 | UniProt (P49327) Pfam (PF00975) In PDB | Homo sapiens (human) | |
| 2 | A, B | (2S,3S,5S)-5-[(N-FORMYL-L-LEUCYL)OXY]-2-HEXYL-3-HYDROXYHEXADECANOIC ACID | non-polymer | 513.8 | 2 | Chemie (DH9) | |||
| 3 | B | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 1 | Chemie (DTT) | |||
| 4 | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A, B: 2200 - 2511 (UniProt: P49327)
| PDB | External Database | Details |
|---|---|---|
| Gly 2196 | - | cloning artifact |
| Ser 2197 | - | cloning artifact |
| His 2198 | - | cloning artifact |
| Asn 2199 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69462.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1181.8 | |
| All* | Total formula weight | 70644.2 |
