2PX6
Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE DH9 A 3000 |
Chain | Residue |
A | LEU2222 |
A | PHE2423 |
A | HIS2481 |
A | ARG2482 |
A | PRO2249 |
A | ILE2250 |
A | GLU2251 |
A | SER2308 |
A | TYR2309 |
A | TYR2343 |
A | ALA2363 |
A | PHE2370 |
site_id | AC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE DH9 B 61 |
Chain | Residue |
B | HOH5 |
B | SER2308 |
B | TYR2309 |
B | TYR2343 |
B | ALA2363 |
B | PHE2370 |
B | GLN2374 |
B | PHE2423 |
B | GLU2431 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE DTT B 71 |
Chain | Residue |
A | LEU2279 |
A | ASP2280 |
A | SER2422 |
A | TYR2425 |
B | SER2281 |
B | HIS2283 |
B | SER2284 |
B | ALA2287 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: For thioesterase activity => ECO:0000255|PROSITE-ProRule:PRU10022, ECO:0000269|PubMed:17618296 |
Chain | Residue | Details |
A | SER2308 | |
B | SER2308 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: For thioesterase activity => ECO:0000255|PROSITE-ProRule:PRU10022 |
Chain | Residue | Details |
A | HIS2481 | |
B | HIS2481 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | THR2204 | |
B | THR2204 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | THR2215 | |
B | THR2215 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
A | SER2236 | |
B | SER2236 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P19096 |
Chain | Residue | Details |
A | LYS2391 | |
B | LYS2391 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25114211 |
Chain | Residue | Details |
A | LYS2449 | |
B | LYS2449 |