2PX6
Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE DH9 A 3000 |
| Chain | Residue |
| A | LEU2222 |
| A | PHE2423 |
| A | HIS2481 |
| A | ARG2482 |
| A | PRO2249 |
| A | ILE2250 |
| A | GLU2251 |
| A | SER2308 |
| A | TYR2309 |
| A | TYR2343 |
| A | ALA2363 |
| A | PHE2370 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DH9 B 61 |
| Chain | Residue |
| B | HOH5 |
| B | SER2308 |
| B | TYR2309 |
| B | TYR2343 |
| B | ALA2363 |
| B | PHE2370 |
| B | GLN2374 |
| B | PHE2423 |
| B | GLU2431 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DTT B 71 |
| Chain | Residue |
| A | LEU2279 |
| A | ASP2280 |
| A | SER2422 |
| A | TYR2425 |
| B | SER2281 |
| B | HIS2283 |
| B | SER2284 |
| B | ALA2287 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For thioesterase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU10022","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17618296","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For thioesterase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU10022","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P19096","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
