2PV9
Crystal structure of murine thrombin in complex with the extracellular fragment of murine PAR4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Thrombin light chain | polymer | 44 | 5105.7 | 1 | UniProt (P19221) Pfam (PF09396) | Mus musculus (house mouse) | |
| 2 | B (B) | Thrombin heavy chain | polymer | 258 | 29952.6 | 1 | UniProt (P19221) Pfam (PF00089) | Mus musculus (house mouse) | |
| 3 | C (C) | Proteinase-activated receptor 4 | polymer | 26 | 2841.1 | 1 | UniProt (O88634) | PAR-4, Thrombin receptor-like 3, Coagulation factor II receptor-like 3 | |
| 4 | D, E (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
B: 16 - 246 (UniProt: P19221)
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Ser 565 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 37899.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 38341.9 |
