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2PV9

Crystal structure of murine thrombin in complex with the extracellular fragment of murine PAR4

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0005576cellular_componentextracellular region
A0006508biological_processproteolysis
A0007596biological_processblood coagulation
B0004252molecular_functionserine-type endopeptidase activity
B0005509molecular_functioncalcium ion binding
B0006508biological_processproteolysis
B0007596biological_processblood coagulation
C0007596biological_processblood coagulation
C0015057molecular_functionthrombin-activated receptor activity
C0016020cellular_componentmembrane
C0070493biological_processthrombin-activated receptor signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
ChainResidueDetails
BLEU53-CYS58

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by thrombin => ECO:0000250
ChainResidueDetails
CARG59
BASP102
BALA195

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN68
BASN186

218853

PDB entries from 2024-04-24

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