2PJL
Crystal Structure of Human Estrogen-Related Receptor alpha in Complex with a Synthetic Inverse Agonist reveals its Novel Molecular Mechanism
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Steroid hormone receptor ERR1 | polymer | 247 | 27017.1 | 2 | UniProt (P11474) Pfam (PF00104) | Homo sapiens (human) | Estrogen-related receptor, alpha, ERR- alpha, Estrogen receptor-like 1 |
| 2 | C, D (A, B) | 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE | non-polymer | 332.5 | 2 | Chemie (047) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 236 | Chemie (HOH) |
Sequence modifications
A, B: 289 - 519 (UniProt: P11474)
| PDB | External Database | Details |
|---|---|---|
| Gly 273 | - | cloning artifact |
| Ser 274 | - | cloning artifact |
| Ser 275 | - | cloning artifact |
| His 276 | - | cloning artifact |
| His 277 | - | cloning artifact |
| His 278 | - | cloning artifact |
| His 279 | - | cloning artifact |
| His 280 | - | cloning artifact |
| His 281 | - | cloning artifact |
| Leu 282 | - | cloning artifact |
| Glu 283 | - | cloning artifact |
| Val 284 | - | cloning artifact |
| Leu 285 | - | cloning artifact |
| Phe 286 | - | cloning artifact |
| Gln 287 | - | cloning artifact |
| Gly 288 | - | cloning artifact |
| Ser 325 | Cys 325 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54034.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 665.0 | |
| All* | Total formula weight | 54699.2 |
