2P6X
Crystal structure of human tyrosine phosphatase PTPN22
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein phosphatase non-receptor type 22 | polymer | 309 | 36514.8 | 2 | UniProt (Q9Y2R2) Pfam (PF00102) | Homo sapiens (human) | Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, Lymphoid phosphatase, LyP |
| 2 | C, D, E, G (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 3 | F (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 369 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 302 (UniProt: Q9Y2R2)
| PDB | External Database | Details |
|---|---|---|
| Ala 303 | - | cloning artifact |
| His 304 | - | cloning artifact |
| His 305 | - | cloning artifact |
| His 306 | - | cloning artifact |
| His 307 | - | cloning artifact |
| His 308 | - | cloning artifact |
| His 309 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73029.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 283.7 | |
| All* | Total formula weight | 73313.4 |
