2P6B
Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | PVIVIT 14-mer Peptide | polymer | 15 | 1481.7 | 1 | |||
| 2 | B, D (A, C) | Calmodulin-dependent calcineurin A subunit alpha isoform | polymer | 383 | 43991.2 | 2 | UniProt (Q08209) Pfam (PF00149) | Homo sapiens (human) | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; CAM-PRP catalytic subunit |
| 3 | C, E (B, D) | Calcineurin subunit B isoform 1 | polymer | 156 | 17755.2 | 2 | UniProt (P63098) Pfam (PF13499) | Homo sapiens (human) | Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1 |
| 4 | F, M (A, C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | G, N (A, C) | FE (III) ION | non-polymer | 55.8 | 2 | Chemie (FE) | |||
| 6 | H, O (A, C) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 7 | I, J, K, L, P... (B, D) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 8 | T, U, V, W, X (E, A, B, C, D) | water | water | 18.0 | 564 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 380 (UniProt: Q08209)
B, D: 15 - 169 (UniProt: P63098)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | cloning artifact |
| Ser -1 | - | cloning artifact |
| His 0 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Met 14 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 124974.4 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 753.1 | |
| All* | Total formula weight | 125727.5 |
