2P6B

Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	E	PVIVIT 14-mer Peptide	polymer	15	1481.7	1
2	A, C	Calmodulin-dependent calcineurin A subunit alpha isoform	polymer	383	43991.2	2	UniProt (Q08209) Pfam (PF00149) In PDB	Homo sapiens (human)	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; CAM-PRP catalytic subunit
3	B, D	Calcineurin subunit B isoform 1	polymer	156	17755.2	2	UniProt (P63098) Pfam (PF13499) In PDB	Homo sapiens (human)	Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1
4	A, C	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	A, C	FE (III) ION	non-polymer		55.8	2	Chemie (FE)
6	A, C	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
7	B, D	CALCIUM ION	non-polymer		40.1	8	Chemie (CA)
8		water	water		18.0	564	Chemie (HOH)

Sequence modifications

A, C: 1 - 380 (UniProt: Q08209)

PDB	External Database	Details
Gly -2	-	cloning artifact
Ser -1	-	cloning artifact
His 0	-	cloning artifact

B, D: 15 - 169 (UniProt: P63098)

PDB	External Database	Details
Met 14	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	124974.4
Non-Polymers*	Number of molecules	14
	Total formula weight	753.1
All*	Total formula weight	125727.5

*Water molecules are not included.