Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

2P6B

Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0016787molecular_functionhydrolase activity
A0033192molecular_functioncalmodulin-dependent protein phosphatase activity
A0097720biological_processcalcineurin-mediated signaling
B0001569biological_processbranching involved in blood vessel morphogenesis
B0001837biological_processepithelial to mesenchymal transition
B0004721molecular_functionphosphoprotein phosphatase activity
B0004723molecular_functioncalcium-dependent protein serine/threonine phosphatase activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005955cellular_componentcalcineurin complex
B0006606biological_processprotein import into nucleus
B0007507biological_processheart development
B0008287cellular_componentprotein serine/threonine phosphatase complex
B0008597molecular_functioncalcium-dependent protein serine/threonine phosphatase regulator activity
B0014044biological_processSchwann cell development
B0019902molecular_functionphosphatase binding
B0019904molecular_functionprotein domain specific binding
B0022011biological_processmyelination in peripheral nervous system
B0033173biological_processcalcineurin-NFAT signaling cascade
B0034504biological_processprotein localization to nucleus
B0042383cellular_componentsarcolemma
B0045202cellular_componentsynapse
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046872molecular_functionmetal ion binding
B0060487biological_processlung epithelial cell differentiation
B0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098686cellular_componenthippocampal mossy fiber to CA3 synapse
B0098688cellular_componentparallel fiber to Purkinje cell synapse
B0098693biological_processregulation of synaptic vesicle cycle
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099149biological_processregulation of postsynaptic neurotransmitter receptor internalization
B0099170biological_processpostsynaptic modulation of chemical synaptic transmission
B1905665biological_processpositive regulation of calcium ion import across plasma membrane
B1905949biological_processnegative regulation of calcium ion import across plasma membrane
C0016787molecular_functionhydrolase activity
C0033192molecular_functioncalmodulin-dependent protein phosphatase activity
C0097720biological_processcalcineurin-mediated signaling
D0001569biological_processbranching involved in blood vessel morphogenesis
D0001837biological_processepithelial to mesenchymal transition
D0004721molecular_functionphosphoprotein phosphatase activity
D0004723molecular_functioncalcium-dependent protein serine/threonine phosphatase activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005955cellular_componentcalcineurin complex
D0006606biological_processprotein import into nucleus
D0007507biological_processheart development
D0008287cellular_componentprotein serine/threonine phosphatase complex
D0008597molecular_functioncalcium-dependent protein serine/threonine phosphatase regulator activity
D0014044biological_processSchwann cell development
D0019902molecular_functionphosphatase binding
D0019904molecular_functionprotein domain specific binding
D0022011biological_processmyelination in peripheral nervous system
D0033173biological_processcalcineurin-NFAT signaling cascade
D0034504biological_processprotein localization to nucleus
D0042383cellular_componentsarcolemma
D0045202cellular_componentsynapse
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046872molecular_functionmetal ion binding
D0060487biological_processlung epithelial cell differentiation
D0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098686cellular_componenthippocampal mossy fiber to CA3 synapse
D0098688cellular_componentparallel fiber to Purkinje cell synapse
D0098693biological_processregulation of synaptic vesicle cycle
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099149biological_processregulation of postsynaptic neurotransmitter receptor internalization
D0099170biological_processpostsynaptic modulation of chemical synaptic transmission
D1905665biological_processpositive regulation of calcium ion import across plasma membrane
D1905949biological_processnegative regulation of calcium ion import across plasma membrane
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ZN A 509
ChainResidue
AASP118
AASN150
AHIS199
AHIS281
AFE510
APO4511

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE FE A 510
ChainResidue
AZN509
APO4511
AHOH673
AASP90
AHIS92
AASP118

site_idAC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE PO4 A 511
ChainResidue
AHIS92
AASP118
AARG122
AASN150
AHIS151
AARG254
AHIS281
AZN509
AFE510
AHOH538
AHOH554
AHOH615

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 501
ChainResidue
BASP30
BASP32
BSER34
BSER36
BGLU41
BGLU68

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 502
ChainResidue
BASP62
BASP64
BASN66
BGLU68
BGLU73
BHOH530

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 503
ChainResidue
BASP99
BASP101
BASP103
BTYR105
BGLU110
BHOH521

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 504
ChainResidue
BASP140
BASP142
BASP144
BARG146
BGLU151
BHOH532

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ZN C 512
ChainResidue
CASP118
CASN150
CHIS199
CHIS281
CFE513
CPO4514

site_idAC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE FE C 513
ChainResidue
CASP90
CHIS92
CASP118
CZN512
CPO4514
CHOH603

site_idBC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE PO4 C 514
ChainResidue
CHIS92
CASP118
CARG122
CASN150
CHIS151
CARG254
CHIS281
CZN512
CFE513
CHOH611
CHOH623

site_idBC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA D 505
ChainResidue
DASP30
DASP32
DSER34
DSER36
DGLU41
DHOH533

site_idBC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA D 506
ChainResidue
DASP62
DASP64
DASN66
DGLU68
DGLU73
DHOH528

site_idBC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA D 507
ChainResidue
DASP99
DASP101
DASP103
DTYR105
DGLU110
DHOH523

site_idBC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA D 508
ChainResidue
DASP140
DASP142
DASP144
DARG146
DGLU151
DHOH530

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DLDNSGSLSveEF
ChainResidueDetails
BASP30-PHE42
BASP62-PHE74
BASP99-LEU111
BASP140-PHE152

site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
ALEU147-GLU152

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues30
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
ChainResidueDetails
BASP30
BGLU73
BASP140
BASP142
BASP144
BARG146
BGLU151
DASP30
DASP32
DSER34
DSER36
BASP32
DGLU41
DASP62
DASP64
DASN66
DGLU68
DGLU73
DASP140
DASP142
DASP144
DARG146
BSER34
DGLU151
BSER36
BGLU41
BASP62
BASP64
BASN66
BGLU68

site_idSWS_FT_FI2
Number of Residues10
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:8524402, ECO:0000312|PDB:6NUC, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
ChainResidueDetails
BASP99
DGLU110
CHIS199
CHIS281
BASP101
BASP103
BTYR105
BGLU110
DASP99
DASP101
DASP103
DTYR105

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Interaction with PxVP motif in substrates of the catalytic subunit => ECO:0000269|PubMed:23468591
ChainResidueDetails
BMET117
BASN121
DMET117
DASN121

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q63810
ChainResidueDetails
BTYR105
DTYR105

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:P63328
ChainResidueDetails
ATYR224
CTYR224

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1aui
ChainResidueDetails
AASP121
AHIS151

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1aui
ChainResidueDetails
CASP121
CHIS151

site_idMCSA1
Number of Residues10
DetailsM-CSA 406
ChainResidueDetails
AASP90metal ligand
AHIS281metal ligand
AHIS92metal ligand
AASP118metal ligand
AASP121electrostatic stabiliser
AARG122transition state stabiliser
AASN150metal ligand
AHIS151proton shuttle (general acid/base)
AHIS199metal ligand
AARG254transition state stabiliser

site_idMCSA2
Number of Residues10
DetailsM-CSA 406
ChainResidueDetails
CASP90metal ligand
CHIS281metal ligand
CHIS92metal ligand
CASP118metal ligand
CASP121electrostatic stabiliser
CARG122transition state stabiliser
CASN150metal ligand
CHIS151proton shuttle (general acid/base)
CHIS199metal ligand
CARG254transition state stabiliser

229183

PDB entries from 2024-12-18

PDB statisticsPDBj update infoContact PDBjnumon