2P1C

T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-210

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Farnesyl pyrophosphate synthase	polymer	390	44475.7	2	UniProt (Q86C09) Pfam (PF00348) In PDB	Trypanosoma brucei
2	A, B	MAGNESIUM ION	non-polymer		24.3	6	Chemie (MG)
3	A, B	ACETATE ION	non-polymer		59.0	3	Chemie (ACT)
4	A, B	{1-HYDROXY-3-[METHYL(4-PHENYLBUTYL)AMINO]PROPANE-1,1-DIYL}BIS(PHOSPHONIC ACID)	non-polymer		381.3	2	Chemie (GG3)
5	B	BETA-MERCAPTOETHANOL	non-polymer		78.1	1	Chemie (BME)
6		water	water		18.0	306	Chemie (HOH)

Sequence modifications

A, B: 1 - 367 (UniProt: Q86C09)

PDB	External Database	Details
Met -22	-	expression tag
Gly -21	-	expression tag
Ser -20	-	expression tag
Ser -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
Ser -12	-	expression tag
Ser -11	-	expression tag
Gly -10	-	expression tag
Leu -9	-	expression tag
Val -8	-	expression tag
Pro -7	-	expression tag
Arg -6	-	expression tag
Gly -5	-	expression tag
Ser -4	-	expression tag
His -3	-	expression tag
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	88951.5
Non-Polymers*	Number of molecules	12
	Total formula weight	1163.7
All*	Total formula weight	90115.2

*Water molecules are not included.