2OXW
Human MMP-12 complexed with the peptide IAG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Macrophage metalloelastase | polymer | 159 | 17615.7 | 1 | UniProt (P39900) Pfam (PF00413) | Homo sapiens (human) | HME, Matrix metalloproteinase-12, MMP-12, Macrophage elastase, ME |
| 2 | B (X) | ILE-ALA-GLY peptide | polymer | 3 | 259.3 | 1 | |||
| 3 | C, D (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E, F, G (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 5 | H, I (A, X) | water | water | 18.0 | 199 | Chemie (HOH) |
Sequence modifications
A: 106 - 263 (UniProt: P39900)
| PDB | External Database | Details |
|---|---|---|
| Met 105 | - | initiating methionine |
| Asp 171 | Phe 171 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 17875.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 251.1 | |
| All* | Total formula weight | 18126.0 |
