2OJW

Crystal structure of human glutamine synthetase in complex with ADP and phosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E	Glutamine synthetase	polymer	384	43364.8	5	UniProt (P15104) Pfam (PF03951) Pfam (PF00120) In PDB	Homo sapiens (human)	Glutamate-ammonia ligase, GS
2	A, D, E, B, C	MANGANESE (II) ION	non-polymer		54.9	20	Chemie (MN)
3	C, A, D, E, B	PHOSPHATE ION	non-polymer		95.0	5	Chemie (PO4)
4	C, A, D, B	CHLORIDE ION	non-polymer		35.5	5	Chemie (CL)
5	C, D, A, E, B	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	5	Chemie (ADP)
6	C, D, A, E, B	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
7		water	water		18.0	1390	Chemie (HOH)

Sequence modifications

A, B, C, D, E: 5 - 365 (UniProt: P15104)

PDB	External Database	Details
Met -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
Gly -9	-	expression tag
Val -8	-	expression tag
Asp -7	-	expression tag
Leu -6	-	expression tag
Gly -5	-	expression tag
Thr -4	-	expression tag
Glu -3	-	expression tag
Asn -2	-	expression tag
Leu -1	-	expression tag
Tyr 0	-	expression tag
Phe 1	-	expression tag
Gln 2	-	expression tag
Ser 3	-	expression tag
Met 4	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	216823.9
Non-Polymers*	Number of molecules	41
	Total formula weight	4439.4
All*	Total formula weight	221263.3

*Water molecules are not included.