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2OJW

Crystal structure of human glutamine synthetase in complex with ADP and phosphate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001525biological_processangiogenesis
A0003824molecular_functioncatalytic activity
A0004356molecular_functionglutamine synthetase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006538biological_processL-glutamate catabolic process
A0006542biological_processglutamine biosynthetic process
A0008283biological_processcell population proliferation
A0009267biological_processcellular response to starvation
A0009749biological_processresponse to glucose
A0010594biological_processregulation of endothelial cell migration
A0016740molecular_functiontransferase activity
A0016874molecular_functionligase activity
A0018345biological_processprotein palmitoylation
A0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
A0042254biological_processribosome biogenesis
A0042802molecular_functionidentical protein binding
A0044297cellular_componentcell body
A0045648biological_processpositive regulation of erythrocyte differentiation
A0046872molecular_functionmetal ion binding
A0070062cellular_componentextracellular exosome
A0097275biological_processintracellular ammonium homeostasis
A0097386cellular_componentglial cell projection
A1903670biological_processregulation of sprouting angiogenesis
A1904749biological_processregulation of protein localization to nucleolus
B0000166molecular_functionnucleotide binding
B0001525biological_processangiogenesis
B0003824molecular_functioncatalytic activity
B0004356molecular_functionglutamine synthetase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006538biological_processL-glutamate catabolic process
B0006542biological_processglutamine biosynthetic process
B0008283biological_processcell population proliferation
B0009267biological_processcellular response to starvation
B0009749biological_processresponse to glucose
B0010594biological_processregulation of endothelial cell migration
B0016740molecular_functiontransferase activity
B0016874molecular_functionligase activity
B0018345biological_processprotein palmitoylation
B0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
B0042254biological_processribosome biogenesis
B0042802molecular_functionidentical protein binding
B0044297cellular_componentcell body
B0045648biological_processpositive regulation of erythrocyte differentiation
B0046872molecular_functionmetal ion binding
B0070062cellular_componentextracellular exosome
B0097275biological_processintracellular ammonium homeostasis
B0097386cellular_componentglial cell projection
B1903670biological_processregulation of sprouting angiogenesis
B1904749biological_processregulation of protein localization to nucleolus
C0000166molecular_functionnucleotide binding
C0001525biological_processangiogenesis
C0003824molecular_functioncatalytic activity
C0004356molecular_functionglutamine synthetase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006538biological_processL-glutamate catabolic process
C0006542biological_processglutamine biosynthetic process
C0008283biological_processcell population proliferation
C0009267biological_processcellular response to starvation
C0009749biological_processresponse to glucose
C0010594biological_processregulation of endothelial cell migration
C0016740molecular_functiontransferase activity
C0016874molecular_functionligase activity
C0018345biological_processprotein palmitoylation
C0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
C0042254biological_processribosome biogenesis
C0042802molecular_functionidentical protein binding
C0044297cellular_componentcell body
C0045648biological_processpositive regulation of erythrocyte differentiation
C0046872molecular_functionmetal ion binding
C0070062cellular_componentextracellular exosome
C0097275biological_processintracellular ammonium homeostasis
C0097386cellular_componentglial cell projection
C1903670biological_processregulation of sprouting angiogenesis
C1904749biological_processregulation of protein localization to nucleolus
D0000166molecular_functionnucleotide binding
D0001525biological_processangiogenesis
D0003824molecular_functioncatalytic activity
D0004356molecular_functionglutamine synthetase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006538biological_processL-glutamate catabolic process
D0006542biological_processglutamine biosynthetic process
D0008283biological_processcell population proliferation
D0009267biological_processcellular response to starvation
D0009749biological_processresponse to glucose
D0010594biological_processregulation of endothelial cell migration
D0016740molecular_functiontransferase activity
D0016874molecular_functionligase activity
D0018345biological_processprotein palmitoylation
D0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
D0042254biological_processribosome biogenesis
D0042802molecular_functionidentical protein binding
D0044297cellular_componentcell body
D0045648biological_processpositive regulation of erythrocyte differentiation
D0046872molecular_functionmetal ion binding
D0070062cellular_componentextracellular exosome
D0097275biological_processintracellular ammonium homeostasis
D0097386cellular_componentglial cell projection
D1903670biological_processregulation of sprouting angiogenesis
D1904749biological_processregulation of protein localization to nucleolus
E0000166molecular_functionnucleotide binding
E0001525biological_processangiogenesis
E0003824molecular_functioncatalytic activity
E0004356molecular_functionglutamine synthetase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006538biological_processL-glutamate catabolic process
E0006542biological_processglutamine biosynthetic process
E0008283biological_processcell population proliferation
E0009267biological_processcellular response to starvation
E0009749biological_processresponse to glucose
E0010594biological_processregulation of endothelial cell migration
E0016740molecular_functiontransferase activity
E0016874molecular_functionligase activity
E0018345biological_processprotein palmitoylation
E0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
E0042254biological_processribosome biogenesis
E0042802molecular_functionidentical protein binding
E0044297cellular_componentcell body
E0045648biological_processpositive regulation of erythrocyte differentiation
E0046872molecular_functionmetal ion binding
E0070062cellular_componentextracellular exosome
E0097275biological_processintracellular ammonium homeostasis
E0097386cellular_componentglial cell projection
E1903670biological_processregulation of sprouting angiogenesis
E1904749biological_processregulation of protein localization to nucleolus
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN A 401
ChainResidue
AGLU136
AGLU196
AGLU203
AMN404
APO4502
AHOH1686

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN A 402
ChainResidue
AARG340
AADP501
APO4502
AGLU134
AHIS253
AGLU338

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN A 403
ChainResidue
AGLU134
AGLU203
AADP501
APO4502
AHOH1635

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN A 404
ChainResidue
AGLU196
AMN401
APO4502
AHOH1729
AHOH1730
AHOH1731

site_idAC5
Number of Residues16
DetailsBINDING SITE FOR RESIDUE PO4 A 502
ChainResidue
AGLU134
AGLU136
AGLU196
AGLU203
AHIS253
AARG319
AGLU338
AARG340
AMN401
AMN402
AMN403
AMN404
AADP501
AHOH1686
AHOH1730
AHOH1786

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN B 401
ChainResidue
BGLU136
BGLU196
BGLU203
BMN404
BPO4502
BHOH1747

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN B 402
ChainResidue
BGLU134
BHIS253
BGLU338
BARG340
BADP501
BPO4502

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN B 403
ChainResidue
BGLU134
BGLU203
BADP501
BPO4502
BHOH1616

site_idAC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN B 404
ChainResidue
BGLU196
BMN401
BPO4502
BHOH1730
BHOH1738
BHOH1739
BHOH1740

site_idBC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE PO4 B 502
ChainResidue
BGLU134
BGLU136
BGLU196
BGLU203
BHIS253
BARG319
BGLU338
BARG340
BMN401
BMN402
BMN403
BMN404
BADP501
BHOH1616
BHOH1740

site_idBC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN C 401
ChainResidue
CGLU136
CGLU196
CGLU203
CMN404
CPO4502
CHOH1745

site_idBC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN C 402
ChainResidue
CGLU134
CHIS253
CGLU338
CARG340
CADP501
CPO4502

site_idBC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN C 403
ChainResidue
CGLU134
CGLU203
CADP501
CPO4502
CHOH1604

site_idBC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN C 404
ChainResidue
CHOH1718
CHOH1719
BHOH1741
CGLU196
CMN401
CPO4502

site_idBC6
Number of Residues17
DetailsBINDING SITE FOR RESIDUE PO4 C 502
ChainResidue
BHOH1741
CGLU134
CGLU136
CGLU196
CGLU203
CHIS253
CARG319
CGLU338
CARG340
CMN401
CMN402
CMN403
CMN404
CADP501
CHOH1707
CHOH1718
CHOH1745

site_idBC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN D 401
ChainResidue
DGLU136
DGLU196
DGLU203
DMN404
DPO4502
DHOH1741

site_idBC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN D 402
ChainResidue
DGLU134
DHIS253
DGLU338
DARG340
DADP501
DPO4502

site_idBC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN D 403
ChainResidue
DGLU134
DGLU203
DADP501
DPO4502
DHOH1615

site_idCC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN D 404
ChainResidue
DGLU196
DMN401
DPO4502
DHOH1609
DHOH1739
DHOH1740

site_idCC2
Number of Residues17
DetailsBINDING SITE FOR RESIDUE PO4 D 502
ChainResidue
DGLU134
DGLU136
DGLU196
DGLU203
DHIS253
DARG319
DGLU338
DARG340
DMN401
DMN402
DMN403
DMN404
DADP501
DHOH1598
DHOH1739
DHOH1740
DHOH1741

site_idCC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN E 401
ChainResidue
EGLU136
EGLU196
EGLU203
EMN404
EPO4502
EHOH1666

site_idCC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN E 402
ChainResidue
EGLU134
EHIS253
EGLU338
EARG340
EADP501
EPO4502

site_idCC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN E 403
ChainResidue
EGLU134
EGLU203
EADP501
EPO4502
EHOH1609

site_idCC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN E 404
ChainResidue
EGLU136
EGLU196
EMN401
EPO4502
EHOH1611
EHOH1716
EHOH1717

site_idCC7
Number of Residues15
DetailsBINDING SITE FOR RESIDUE PO4 E 502
ChainResidue
EGLU134
EGLU136
EGLU196
EGLU203
EHIS253
EARG319
EGLU338
EARG340
EMN401
EMN402
EMN403
EMN404
EADP501
EHOH1699
EHOH1716

site_idCC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL B 1401
ChainResidue
BTHR44
CTHR193

site_idCC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL C 1402
ChainResidue
CMET29
CTHR44
DTHR193

site_idDC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 1403
ChainResidue
ATHR193
ETHR44

site_idDC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL D 1404
ChainResidue
DTHR44
ETHR193
EHOH1531

site_idDC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 1405
ChainResidue
ATHR44
BTHR193

site_idDC4
Number of Residues23
DetailsBINDING SITE FOR RESIDUE ADP A 501
ChainResidue
ATRP130
AGLY132
AGLU134
AGLU203
AGLN205
AGLY207
APRO208
AASN255
ASER257
AARG319
AARG324
ATYR336
AGLU338
AMN402
AMN403
APO4502
AHOH1540
AHOH1587
AHOH1619
AHOH1620
AHOH1635
AHOH1664
EHOH1513

site_idDC5
Number of Residues23
DetailsBINDING SITE FOR RESIDUE ADP B 501
ChainResidue
AHOH1575
BTRP130
BGLY132
BGLU134
BGLU203
BGLN205
BGLY207
BPRO208
BASN255
BSER257
BARG319
BARG324
BTYR336
BGLU338
BMN402
BMN403
BPO4502
BHOH1560
BHOH1570
BHOH1589
BHOH1616
BHOH1693
BHOH1753

site_idDC6
Number of Residues23
DetailsBINDING SITE FOR RESIDUE ADP C 501
ChainResidue
CTRP130
CGLY132
CGLU134
CGLU203
CGLN205
CGLY207
CPRO208
CASN255
CSER257
CARG319
CARG324
CTYR336
CGLU338
CMN402
CMN403
CPO4502
CHOH1584
CHOH1600
CHOH1603
CHOH1604
CHOH1656
CHOH1674
CHOH1681

site_idDC7
Number of Residues24
DetailsBINDING SITE FOR RESIDUE ADP D 501
ChainResidue
DTRP130
DGLY132
DGLU134
DGLU203
DGLN205
DGLY207
DPRO208
DASN255
DSER257
DARG319
DARG324
DTYR336
DGLU338
DMN402
DMN403
DPO4502
DHOH1585
DHOH1597
DHOH1615
DHOH1628
DHOH1631
DHOH1636
DHOH1716
DHOH1750

site_idDC8
Number of Residues23
DetailsBINDING SITE FOR RESIDUE ADP E 501
ChainResidue
DHOH1617
ETRP130
EGLY132
EGLU134
EGLU203
EGLN205
EGLY207
EPRO208
EASN255
ESER257
EARG262
EARG319
EARG324
ETYR336
EGLU338
EMN402
EMN403
EPO4502
EHOH1540
EHOH1555
EHOH1609
EHOH1636
EHOH1644

site_idDC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 1501
ChainResidue
ALYS14
APRO88
APHE89
AHOH1543
AHOH1665
AHOH1694

site_idEC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 1502
ChainResidue
ATYR17
BLYS14
BPRO88
BPHE89
BHOH1548
BHOH1674
BHOH1748
BHOH1756

site_idEC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL C 1503
ChainResidue
CLYS14
CPRO88
CPHE89
CHOH1557
CHOH1734

site_idEC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL D 1504
ChainResidue
DLYS14
DPRO88
DPHE89
DHOH1601
DHOH1752

site_idEC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL E 1505
ChainResidue
DVAL16
ELYS14
EPRO88
EPHE89
EHOH1557
EHOH1594
EHOH1642

site_idEC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL C 1506
ChainResidue
CALA82
CSER213
CASP216
CHIS217
CHOH1781

Functional Information from PROSITE/UniProt
site_idPS00180
Number of Residues18
DetailsGLNA_1 Glutamine synthetase signature 1. FDGSStlqsegs.NSDmyL
ChainResidueDetails
APHE62-LEU79

site_idPS00181
Number of Residues17
DetailsGLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPIpgnw.NGAGcHtnfS
ChainResidueDetails
ALYS241-SER257

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues410
DetailsDomain: {"description":"GS beta-grasp","evidences":[{"source":"PROSITE-ProRule","id":"PRU01330","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues30
DetailsBinding site: {"evidences":[{"source":"PDB","id":"2QC8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues50
DetailsBinding site: {"evidences":[{"source":"PDB","id":"2OJW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QC8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues15
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P9WN39","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues10
DetailsModified residue: {"description":"N6-acetyllysine; by EP300","evidences":[{"source":"PubMed","id":"26990986","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues5
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P15105","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues5
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
AARG319
AASP63

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
BARG319
BASP63

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
CARG319
CASP63

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
DARG319
DASP63

site_idCSA5
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
EARG319
EASP63

243083

PDB entries from 2025-10-15

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