2OJ9
Structure of IGF-1R kinase domain complexed with a benzimidazole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) | polymer | 307 | 35041.2 | 1 | UniProt (P08069) Pfam (PF07714) | Homo sapiens (human) | CD221 ANTIGEN, IGF1R |
| 2 | B (A) | 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE | non-polymer | 397.4 | 1 | Chemie (BMI) | |||
| 3 | C (A) | water | water | 18.0 | 204 | Chemie (HOH) |
Sequence modifications
A: 952 - 1256 (UniProt: P08069)
| PDB | External Database | Details |
|---|---|---|
| Met 950 | - | cloning artifact |
| Val 951 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35041.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 397.4 | |
| All* | Total formula weight | 35438.7 |
