2OIP
Crystal Structure of the S290G Active Site Mutant of TS-DHFR from Cryptosporidium hominis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Chain A, crystal structure of Dhfr | polymer | 519 | 60014.2 | 5 | UniProt (Q5CGA3) | Cryptosporidium hominis | |
| 2 | F, J, N, R, V (A, B, C, D, E) | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 5 | Chemie (UMP) | |||
| 3 | G, K, O, S, W (A, B, C, D, E) | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID | non-polymer | 477.5 | 5 | Chemie (CB3) | |||
| 4 | H, L, P, T, X (A, B, C, D, E) | METHOTREXATE | non-polymer | 454.4 | 5 | Chemie (MTX) | |||
| 5 | I, M, Q, U, Y (A, B, C, D, E) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 5 | Chemie (NDP) | |||
| 6 | AA, BA, CA, DA, Z (B, C, D, E, A) | water | water | 18.0 | 404 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 3 - 521 (UniProt: Q5CGA3)
| PDB | External Database | Details |
|---|---|---|
| Gly 290 | Ser 290 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 300071.1 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 9927.6 | |
| All* | Total formula weight | 309998.6 |
