2OIP
Crystal Structure of the S290G Active Site Mutant of TS-DHFR from Cryptosporidium hominis
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E | Chain A, crystal structure of Dhfr | polymer | 519 | 60014.2 | 5 | UniProt (Q5CGA3) In PDB | Cryptosporidium hominis | |
2 | A, B, C, D, E | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 5 | Chemie (UMP) | |||
3 | A, B, C, D, E | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID | non-polymer | 477.5 | 5 | Chemie (CB3) | |||
4 | A, B, C, D, E | METHOTREXATE | non-polymer | 454.4 | 5 | Chemie (MTX) | |||
5 | A, B, C, D, E | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 5 | Chemie (NDP) | |||
6 | water | water | 18.0 | 404 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 3 - 521 (UniProt: Q5CGA3)
PDB | External Database | Details |
---|---|---|
Gly 290 | Ser 290 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 300071.1 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 9927.6 | |
All* | Total formula weight | 309998.6 |