2OIP
Crystal Structure of the S290G Active Site Mutant of TS-DHFR from Cryptosporidium hominis
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0004799 | molecular_function | thymidylate synthase activity |
A | 0006231 | biological_process | dTMP biosynthetic process |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0004799 | molecular_function | thymidylate synthase activity |
B | 0006231 | biological_process | dTMP biosynthetic process |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
C | 0004146 | molecular_function | dihydrofolate reductase activity |
C | 0004799 | molecular_function | thymidylate synthase activity |
C | 0006231 | biological_process | dTMP biosynthetic process |
C | 0006730 | biological_process | one-carbon metabolic process |
C | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
C | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
D | 0004146 | molecular_function | dihydrofolate reductase activity |
D | 0004799 | molecular_function | thymidylate synthase activity |
D | 0006231 | biological_process | dTMP biosynthetic process |
D | 0006730 | biological_process | one-carbon metabolic process |
D | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
D | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
E | 0004146 | molecular_function | dihydrofolate reductase activity |
E | 0004799 | molecular_function | thymidylate synthase activity |
E | 0006231 | biological_process | dTMP biosynthetic process |
E | 0006730 | biological_process | one-carbon metabolic process |
E | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
E | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGingqLPWsise.DlkfFskiT |
Chain | Residue | Details |
A | GLY18-THR40 |
site_id | PS00091 |
Number of Residues | 29 |
Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrhIltaWNpsalsqma.....LpPCHvlsQYyV |
Chain | Residue | Details |
A | ARG382-VAL410 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 6 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
A | ASP426 | |
A | ASP462 | |
A | GLU294 | |
A | HIS464 | |
A | SER424 | |
A | CYS402 |
site_id | CSA10 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
E | LEU25 | |
E | ASP32 |
site_id | CSA2 |
Number of Residues | 6 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
D | ASP426 | |
D | ASP462 | |
D | GLU294 | |
D | HIS464 | |
D | SER424 | |
D | CYS402 |
site_id | CSA3 |
Number of Residues | 6 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
C | ASP426 | |
C | ASP462 | |
C | GLU294 | |
C | HIS464 | |
C | SER424 | |
C | CYS402 |
site_id | CSA4 |
Number of Residues | 6 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
E | ASP426 | |
E | ASP462 | |
E | GLU294 | |
E | HIS464 | |
E | SER424 | |
E | CYS402 |
site_id | CSA5 |
Number of Residues | 6 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
B | ASP426 | |
B | ASP462 | |
B | GLU294 | |
B | HIS464 | |
B | SER424 | |
B | CYS402 |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
A | LEU25 | |
A | ASP32 |
site_id | CSA7 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
B | LEU25 | |
B | ASP32 |
site_id | CSA8 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
C | LEU25 | |
C | ASP32 |
site_id | CSA9 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
D | LEU25 | |
D | ASP32 |