2OGD

T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-527

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Farnesyl pyrophosphate synthase	polymer	390	44475.7	2	UniProt (Q86C09) Pfam (PF00348) In PDB	Trypanosoma brucei
2	A, B	ACETATE ION	non-polymer		59.0	4	Chemie (ACT)
3	A, B	MAGNESIUM ION	non-polymer		24.3	6	Chemie (MG)
4	A, B	[2-(DIMETHYL-LAMBDA~4~-SULFANYL)-1-HYDROXYETHANE-1,1-DIYL]BIS(PHOSPHONIC ACID)	non-polymer		268.2	2	Chemie (SUF)
5	A, B	BETA-MERCAPTOETHANOL	non-polymer		78.1	3	Chemie (BME)
6	A	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	1	Chemie (MPD)
7		water	water		18.0	564	Chemie (HOH)

Sequence modifications

A, B: 1 - 367 (UniProt: Q86C09)

PDB	External Database	Details
Met -22	-	expression tag
Gly -21	-	expression tag
Ser -20	-	expression tag
Ser -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
Ser -12	-	expression tag
Ser -11	-	expression tag
Gly -10	-	expression tag
Leu -9	-	expression tag
Val -8	-	expression tag
Pro -7	-	expression tag
Arg -6	-	expression tag
Gly -5	-	expression tag
Ser -4	-	expression tag
His -3	-	expression tag
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	88951.5
Non-Polymers*	Number of molecules	16
	Total formula weight	1270.9
All*	Total formula weight	90222.4

*Water molecules are not included.