2ODE

Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Guanine nucleotide-binding protein G(k) subunit alpha	polymer	350	40162.6	2	UniProt (P08754) Pfam (PF00503)	Homo sapiens (human)	Gi, alpha-3
2	B, D (B, D)	Regulator of G-protein signaling 8	polymer	141	16618.9	2	UniProt (P57771) Pfam (PF00615)	Homo sapiens (human)	RGS8
3	E, H (A, C)	TETRAFLUOROALUMINATE ION	non-polymer		103.0	2	Chemie (ALF)
4	F, I (A, C)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	G, J (A, C)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
6	K, L, M, N (A, B, C, D)	water	water		18.0	655	Chemie (HOH)

Sequence modifications

A, C: 4 - 350 (UniProt: P08754)

PDB	External Database	Details
Ser 2	-	expression tag
Met 3	-	expression tag
Ser 351	-	expression tag

B, D: 42 - 180 (UniProt: P57771)

PDB	External Database	Details
Ser 40	-	expression tag
Met 41	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	113562.9
Non-Polymers*	Number of molecules	6
	Total formula weight	1141.0
All*	Total formula weight	114703.9

*Water molecules are not included.