2ODE
Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Guanine nucleotide-binding protein G(k) subunit alpha | polymer | 350 | 40162.6 | 2 | UniProt (P08754) Pfam (PF00503) | Homo sapiens (human) | Gi, alpha-3 |
| 2 | B, D (B, D) | Regulator of G-protein signaling 8 | polymer | 141 | 16618.9 | 2 | UniProt (P57771) Pfam (PF00615) | Homo sapiens (human) | RGS8 |
| 3 | E, H (A, C) | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 2 | Chemie (ALF) PubChem (5311325) | |||
| 4 | F, I (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | G, J (A, C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 6 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 655 | Chemie (HOH) |
Sequence modifications
A, C: 4 - 350 (UniProt: P08754)
B, D: 42 - 180 (UniProt: P57771)
| PDB | External Database | Details |
|---|---|---|
| Ser 2 | - | expression tag |
| Met 3 | - | expression tag |
| Ser 351 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 40 | - | expression tag |
| Met 41 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 113562.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1141.0 | |
| All* | Total formula weight | 114703.9 |
