2O9I
Crystal Structure of the Human Pregnane X Receptor LBD in complex with an SRC-1 coactivator peptide and T0901317
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Orphan nuclear receptor PXR | polymer | 293 | 33676.9 | 2 | UniProt (O75469) Pfam (PF00104) In PDB | Homo sapiens (human) | Pregnane X receptor, Orphan nuclear receptor PAR1, Steroid and xenobiotic receptor, SXR |
| 2 | C, D | Nuclear Receptor Coactivator 1 isoform 3 | polymer | 15 | 1878.2 | 2 | UniProt (by SIFTS) (P70365) In PDB | ||
| 3 | A, B | N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE | non-polymer | 481.3 | 2 | Chemie (444) | |||
| 4 | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A, B: 142 - 434 (UniProt: O75469)
| PDB | External Database | Details |
|---|---|---|
| Ser 284 | Cys 284 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 71110.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 962.7 | |
| All* | Total formula weight | 72072.9 |
