2O8U
Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Urokinase plasminogen activator | polymer | 253 | 28426.4 | 1 | UniProt (Q5PY49) Pfam (PF00089) UniProt (by SIFTS) (P00749) | Homo sapiens (human) | UPA |
| 2 | B (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | C, D (A) | BENZAMIDINE | non-polymer | 120.2 | 2 | Chemie (BEN) | |||
| 4 | E (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 5 | F (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | G (A) | water | water | 18.0 | 201 | Chemie (HOH) |
Sequence modifications
A: 16 - 250 (UniProt: Q5PY49)
| PDB | External Database | Details |
|---|---|---|
| Ala 122 | Cys 279 | engineered mutation |
| Gln 145 | Asn 302 | engineered mutation |
| Ala 195 | Ser 356 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28426.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 636.7 | |
| All* | Total formula weight | 29063.1 |
