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2O8U

Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 A 403
ChainResidue
AHIS57
AGLN192
AGLY193
AALA195
ABEN1193
AHOH5141
AHOH5190
AHOH5228
AHOH5253

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE BEN A 1193
ChainResidue
AASP189
ASER190
AGLY219
ACYS220
AGLY226
ASO4403

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE BEN A 1194
ChainResidue
APHE132
AILE163
ASER164
AHIS165
AARG230
AHOH5307

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PG4 A 5115
ChainResidue
AASN74
ATYR149
ATYR151
ASER202

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PEG A 5084
ChainResidue
ASER71
ATHR77
AHOH5311

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC
ChainResidueDetails
AILE53-CYS58

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS57
AASP102
AALA195

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:9151681
ChainResidueDetails
ASER146

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
AGLN145

220472

PDB entries from 2024-05-29

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