2O8M
Crystal structure of the S139A mutant of Hepatitis C Virus NS3/4A protease
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Protease | polymer | 200 | 21217.2 | 2 | UniProt (Q9ELS8) Pfam (PF02907) UniProt (by SIFTS) (P27958) In PDB | Hepatitis C virus | |
2 | C, D | Protease | polymer | 23 | 2410.1 | 2 | UniProt (P27958) Pfam (PF01006) In PDB | ||
3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
4 | A, C | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
5 | water | water | 18.0 | 235 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 181 (UniProt: Q9ELS8)
C, D: 221 - 239 (UniProt: P27958)
PDB | External Database | Details |
---|---|---|
Met -11 | - | expression tag |
Ala -10 | - | expression tag |
Ser -9 | - | expression tag |
Met -8 | - | expression tag |
Thr -7 | - | expression tag |
Gly -6 | - | expression tag |
Gly -5 | - | expression tag |
Gln -4 | - | expression tag |
Gln -3 | - | expression tag |
Met -2 | - | expression tag |
Gly -1 | - | expression tag |
Arg 119 | Gln 1145 | conflict |
Ala 139 | Ser 1165 | conflict |
Gly 182 | - | expression tag |
Ser 183 | - | expression tag |
His 184 | - | expression tag |
His 185 | - | expression tag |
His 186 | - | expression tag |
His 187 | - | expression tag |
His 188 | - | expression tag |
His 189 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Lys 219 | - | expression tag |
Lys 220 | - | expression tag |
Lys 240 | - | expression tag |
Lys 241 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 47254.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 176.8 | |
All* | Total formula weight | 47431.5 |