2O2F

Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Apoptosis regulator Bcl-2	polymer	138	16366.4	1	UniProt (P10415) Pfam (PF02180) Pfam (PF00452) In PDB	Homo sapiens (human)
2	A	4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE	non-polymer		688.9	1	Chemie (LI0)

Sequence modifications

A: 6 - 29 (UniProt: P10415)
A: 89 - 201 (UniProt: P10415)

PDB	External Database	Details
Glu 48	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	16366.4
Non-Polymers*	Number of molecules	1
	Total formula weight	688.9
All*	Total formula weight	17055.3

*Water molecules are not included.