2O2F

Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042981	biological_process	regulation of apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LI0 A 1000

Chain	Residue
A	ALA97
A	VAL145
A	ALA146
A	TYR199
A	ASP100
A	TYR105
A	ASP108
A	MET112
A	VAL130
A	LEU134
A	TRP141
A	GLY142

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Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	19
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG

Chain	Residue	Details
A	LEU134-GLY152

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site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV

Chain	Residue	Details
A	TRP185-VAL196

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site_id	PS01259
Number of Residues	15
Details	BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VhltLRqAGDDFSRR

Chain	Residue	Details
A	VAL90-ARG104

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site_id	PS01260
Number of Residues	21
Details	BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW

Chain	Residue	Details
A	ASP8-TRP28

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by caspase-3

Chain	Residue	Details
A	VAL90

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by MAPK8 => ECO:0000269|PubMed:18570871

Chain	Residue	Details
A	GLY125

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAPK8 and PKC => ECO:0000269|PubMed:18570871

Chain	Residue	Details
A	ARG126

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:18570871

Chain	Residue	Details
A	ARG143

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