2MZI

NMR Solution Structure of the PRO Form of Human Matrilysin (proMMP-7) in Complex with Anionic Membrane

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Matrilysin	polymer	250	27912.6	1	UniProt (P09237) Pfam (PF01471) Pfam (PF00413)	Homo sapiens (human)	Matrin, Matrix metalloproteinase-7, MMP-7, Pump-1 protease, Uterine metalloproteinase
2	B, C (A)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA) PubChem (271)
3	D, E (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	AA, AB, AC, AD, AE... (A)	1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		678.9	126	Chemie (PX4) PubChem (26198) PubChem (87505) PubChem (5313082)
5	BE, CE, DE, EE, FE... (A)	CHOLEST-5-EN-3-YL HYDROGEN SULFATE	non-polymer		466.7	6	Chemie (C3S) PubChem (18631913) PubChem (18637921) PubChem (25055661) PubChem (34174273) PubChem (44359124) PubChem (65076) PubChem (46936278) PubChem (52934309) PubChem (53683001) PubChem (34174265) PubChem (86318757) PubChem (86318759) PubChem (86318761) PubChem (4259412) PubChem (86310857) PubChem (87292651) PubChem (124301052) PubChem (99569635) PubChem (117705488) PubChem (122130877) PubChem (9847391) PubChem (123134861) PubChem (124225017) PubChem (124225018) PubChem (124225019) PubChem (11969852) PubChem (14189346) PubChem (124904518) PubChem (124904519) PubChem (146156788) PubChem (146460988) PubChem (131697794) PubChem (137705228) PubChem (139468493) PubChem (146663698) PubChem (163452773) PubChem (169650022)

Sequence modifications

A: -2 - 247 (UniProt: P09237)

PDB	External Database	Details
Ala 195	Glu 215	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	27912.6
Non-Polymers*	Number of molecules	136
	Total formula weight	88557.7
All*	Total formula weight	116470.3

*Water molecules are not included.