2MZI
NMR Solution Structure of the PRO Form of Human Matrilysin (proMMP-7) in Complex with Anionic Membrane
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002779 | biological_process | antibacterial peptide secretion |
| A | 0002780 | biological_process | antibacterial peptide biosynthetic process |
| A | 0004175 | molecular_function | endopeptidase activity |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0006509 | biological_process | membrane protein ectodomain proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0022617 | biological_process | extracellular matrix disassembly |
| A | 0030198 | biological_process | extracellular matrix organization |
| A | 0030335 | biological_process | positive regulation of cell migration |
| A | 0030574 | biological_process | collagen catabolic process |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0031293 | biological_process | membrane protein intracellular domain proteolysis |
| A | 0042127 | biological_process | regulation of cell population proliferation |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 301 |
| Chain | Residue |
| A | ASP133 |
| A | GLY165 |
| A | GLY167 |
| A | ASP169 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 302 |
| Chain | Residue |
| A | ASP173 |
| A | GLU176 |
| A | PHE149 |
| A | ASP150 |
| A | GLY151 |
| A | GLY153 |
| A | THR155 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 303 |
| Chain | Residue |
| A | HIS143 |
| A | ASP145 |
| A | HIS158 |
| A | HIS171 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 304 |
| Chain | Residue |
| A | CYS67 |
| A | ASP71 |
| A | HIS194 |
| A | HIS198 |
| A | HIS204 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PX4 A 305 |
| Chain | Residue |
| A | PX4311 |
| A | PX4312 |
| A | PX4324 |
| A | PX4340 |
| A | PX4363 |
| A | C3S431 |
| A | C3S432 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PX4 A 306 |
| Chain | Residue |
| A | THR85 |
| A | SER86 |
| A | LYS87 |
| A | VAL88 |
| A | ARG125 |
| A | PX4318 |
| A | PX4321 |
| A | PX4342 |
| A | PX4358 |
| A | PX4359 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PX4 A 307 |
| Chain | Residue |
| A | LYS118 |
| A | PX4322 |
| A | PX4332 |
| A | PX4337 |
| A | PX4344 |
| A | PX4369 |
| A | PX4423 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PX4 A 308 |
| Chain | Residue |
| A | PX4320 |
| A | PX4326 |
| A | PX4334 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PX4 A 309 |
| Chain | Residue |
| A | PX4345 |
| A | PX4347 |
| A | PX4351 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PX4 A 310 |
| Chain | Residue |
| A | PX4364 |
| A | PX4414 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 311 |
| Chain | Residue |
| A | PX4305 |
| A | PX4324 |
| A | PX4363 |
| A | PX4377 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 312 |
| Chain | Residue |
| A | PX4305 |
| A | PX4324 |
| A | PX4339 |
| A | PX4346 |
| A | PX4363 |
| A | PX4388 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PX4 A 313 |
| Chain | Residue |
| A | PX4355 |
| A | PX4362 |
| A | PX4415 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PX4 A 314 |
| Chain | Residue |
| A | PX4335 |
| A | PX4336 |
| A | PX4354 |
| site_id | BC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PX4 A 315 |
| Chain | Residue |
| A | ARG107 |
| A | SER110 |
| A | LYS111 |
| A | LYS126 |
| A | ASN223 |
| A | PHE224 |
| A | PX4332 |
| A | PX4337 |
| A | PX4350 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 316 |
| Chain | Residue |
| A | TRP129 |
| A | GLY130 |
| A | PX4321 |
| A | PX4343 |
| A | PX4352 |
| A | PX4396 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 317 |
| Chain | Residue |
| A | GLN222 |
| A | ASN223 |
| A | PX4325 |
| A | PX4326 |
| A | PX4330 |
| A | PX4361 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 318 |
| Chain | Residue |
| A | PX4306 |
| A | PX4321 |
| A | PX4342 |
| A | PX4352 |
| A | PX4357 |
| A | PX4358 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PX4 A 319 |
| Chain | Residue |
| A | PX4343 |
| A | PX4352 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 320 |
| Chain | Residue |
| A | PX4308 |
| A | PX4326 |
| A | PX4334 |
| A | PX4418 |
| A | ILE103 |
| A | ARG107 |
| site_id | CC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PX4 A 321 |
| Chain | Residue |
| A | THR90 |
| A | TRP129 |
| A | THR131 |
| A | PX4306 |
| A | PX4316 |
| A | PX4318 |
| A | PX4342 |
| A | PX4375 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 322 |
| Chain | Residue |
| A | PX4307 |
| A | PX4331 |
| A | PX4344 |
| A | PX4398 |
| site_id | CC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PX4 A 323 |
| Chain | Residue |
| A | PX4328 |
| A | PX4353 |
| site_id | CC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PX4 A 324 |
| Chain | Residue |
| A | PX4305 |
| A | PX4311 |
| A | PX4312 |
| A | PX4333 |
| A | PX4334 |
| A | PX4388 |
| A | PX4414 |
| A | C3S431 |
| site_id | CC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PX4 A 325 |
| Chain | Residue |
| A | GLN222 |
| A | PX4317 |
| A | PX4329 |
| A | PX4330 |
| A | PX4353 |
| A | PX4355 |
| A | PX4382 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 326 |
| Chain | Residue |
| A | PX4308 |
| A | PX4317 |
| A | PX4320 |
| A | PX4361 |
| site_id | CC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PX4 A 327 |
| Chain | Residue |
| A | GLY117 |
| A | LYS118 |
| A | ILE120 |
| A | LEU122 |
| A | PX4332 |
| A | PX4348 |
| A | PX4359 |
| A | PX4394 |
| site_id | DC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PX4 A 328 |
| Chain | Residue |
| A | PX4323 |
| site_id | DC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PX4 A 329 |
| Chain | Residue |
| A | PX4325 |
| site_id | DC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PX4 A 330 |
| Chain | Residue |
| A | GLN222 |
| A | ASN223 |
| A | PX4317 |
| A | PX4325 |
| A | PX4331 |
| A | PX4337 |
| A | PX4355 |
| A | PX4362 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 331 |
| Chain | Residue |
| A | PX4322 |
| A | PX4330 |
| A | PX4337 |
| A | PX4344 |
| A | PX4362 |
| site_id | DC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PX4 A 332 |
| Chain | Residue |
| A | ARG107 |
| A | ASN114 |
| A | PX4307 |
| A | PX4315 |
| A | PX4327 |
| A | PX4348 |
| A | PX4350 |
| site_id | DC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 333 |
| Chain | Residue |
| A | PX4324 |
| A | PX4334 |
| A | PX4340 |
| A | PX4364 |
| A | PX4389 |
| A | C3S432 |
| site_id | DC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PX4 A 334 |
| Chain | Residue |
| A | ASP99 |
| A | PRO101 |
| A | ARG177 |
| A | PX4308 |
| A | PX4320 |
| A | PX4324 |
| A | PX4333 |
| A | PX4417 |
| A | C3S431 |
| A | C3S432 |
| A | C3S436 |
| site_id | DC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PX4 A 335 |
| Chain | Residue |
| A | PX4314 |
| A | PX4360 |
| site_id | DC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PX4 A 336 |
| Chain | Residue |
| A | PX4314 |
| A | PX4344 |
| A | PX4354 |
| site_id | EC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PX4 A 337 |
| Chain | Residue |
| A | ASN223 |
| A | LYS225 |
| A | PX4307 |
| A | PX4315 |
| A | PX4330 |
| A | PX4331 |
| A | PX4355 |
| A | PX4362 |
| site_id | EC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 338 |
| Chain | Residue |
| A | PX4344 |
| A | PX4351 |
| A | PX4354 |
| A | PX4374 |
| site_id | EC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PX4 A 339 |
| Chain | Residue |
| A | PX4312 |
| A | PX4363 |
| site_id | EC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PX4 A 340 |
| Chain | Residue |
| A | TYR96 |
| A | PX4305 |
| A | PX4333 |
| A | PX4343 |
| A | PX4350 |
| A | PX4364 |
| A | C3S432 |
| site_id | EC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PX4 A 341 |
| Chain | Residue |
| A | PX4364 |
| site_id | EC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 342 |
| Chain | Residue |
| A | PX4306 |
| A | PX4318 |
| A | PX4321 |
| A | PX4358 |
| site_id | EC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PX4 A 343 |
| Chain | Residue |
| A | ARG92 |
| A | VAL94 |
| A | GLY130 |
| A | PX4316 |
| A | PX4319 |
| A | PX4340 |
| A | PX4350 |
| site_id | EC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PX4 A 344 |
| Chain | Residue |
| A | PX4307 |
| A | PX4322 |
| A | PX4331 |
| A | PX4336 |
| A | PX4338 |
| A | PX4351 |
| A | PX4354 |
| site_id | EC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 345 |
| Chain | Residue |
| A | PX4309 |
| A | PX4358 |
| A | PX4359 |
| A | PX4383 |
| A | PX4396 |
| site_id | FC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PX4 A 346 |
| Chain | Residue |
| A | PX4312 |
| A | C3S431 |
| site_id | FC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PX4 A 347 |
| Chain | Residue |
| A | PX4309 |
| A | PX4351 |
| A | PX4354 |
| site_id | FC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PX4 A 348 |
| Chain | Residue |
| A | TYR91 |
| A | SER110 |
| A | ASN114 |
| A | HIS123 |
| A | PHE124 |
| A | PX4327 |
| A | PX4332 |
| A | PX4359 |
| A | PX4407 |
| site_id | FC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PX4 A 349 |
| Chain | Residue |
| A | PX4361 |
| A | PX4403 |
| site_id | FC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PX4 A 350 |
| Chain | Residue |
| A | ARG92 |
| A | HIS102 |
| A | ASP106 |
| A | LYS126 |
| A | VAL128 |
| A | PX4315 |
| A | PX4332 |
| A | PX4340 |
| A | PX4343 |
| A | PX4370 |
| site_id | FC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 351 |
| Chain | Residue |
| A | PX4309 |
| A | PX4338 |
| A | PX4344 |
| A | PX4347 |
| A | PX4393 |
| site_id | FC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PX4 A 352 |
| Chain | Residue |
| A | PX4316 |
| A | PX4318 |
| A | PX4319 |
| site_id | FC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PX4 A 353 |
| Chain | Residue |
| A | PX4323 |
| A | PX4325 |
| A | PX4361 |
| site_id | FC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 354 |
| Chain | Residue |
| A | PX4314 |
| A | PX4336 |
| A | PX4338 |
| A | PX4344 |
| A | PX4347 |
| A | PX4360 |
| site_id | GC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 355 |
| Chain | Residue |
| A | PX4313 |
| A | PX4325 |
| A | PX4330 |
| A | PX4337 |
| A | PX4362 |
| site_id | GC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PX4 A 357 |
| Chain | Residue |
| A | PX4318 |
| site_id | GC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 358 |
| Chain | Residue |
| A | PX4306 |
| A | PX4318 |
| A | PX4342 |
| A | PX4345 |
| A | PX4359 |
| A | PX4383 |
| site_id | GC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PX4 A 359 |
| Chain | Residue |
| A | LYS87 |
| A | HIS123 |
| A | ARG125 |
| A | PX4306 |
| A | PX4327 |
| A | PX4345 |
| A | PX4348 |
| A | PX4358 |
| A | PX4369 |
| A | PX4376 |
| A | PX4407 |
| site_id | GC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PX4 A 360 |
| Chain | Residue |
| A | PX4335 |
| A | PX4354 |
| site_id | GC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 361 |
| Chain | Residue |
| A | PX4317 |
| A | PX4326 |
| A | PX4349 |
| A | PX4353 |
| site_id | GC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 362 |
| Chain | Residue |
| A | PX4313 |
| A | PX4330 |
| A | PX4331 |
| A | PX4337 |
| A | PX4355 |
| site_id | GC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 363 |
| Chain | Residue |
| A | PX4305 |
| A | PX4311 |
| A | PX4312 |
| A | PX4339 |
| site_id | GC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 364 |
| Chain | Residue |
| A | PX4310 |
| A | PX4333 |
| A | PX4340 |
| A | PX4341 |
| site_id | HC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 365 |
| Chain | Residue |
| A | PX4369 |
| A | PX4383 |
| A | PX4390 |
| A | PX4393 |
| A | PX4396 |
| A | PX4419 |
| site_id | HC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PX4 A 366 |
| Chain | Residue |
| A | PX4378 |
| A | PX4386 |
| A | PX4403 |
| site_id | HC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PX4 A 367 |
| Chain | Residue |
| A | PX4412 |
| site_id | HC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 368 |
| Chain | Residue |
| A | PX4391 |
| A | PX4406 |
| A | PX4408 |
| A | PX4414 |
| A | C3S436 |
| site_id | HC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 369 |
| Chain | Residue |
| A | PX4307 |
| A | PX4359 |
| A | PX4365 |
| A | PX4370 |
| A | PX4383 |
| A | PX4430 |
| site_id | HC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 370 |
| Chain | Residue |
| A | PX4350 |
| A | PX4369 |
| A | PX4381 |
| A | PX4383 |
| A | PX4394 |
| A | PX4430 |
| site_id | HC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 371 |
| Chain | Residue |
| A | PX4373 |
| A | PX4395 |
| A | PX4402 |
| A | PX4426 |
| site_id | HC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PX4 A 372 |
| Chain | Residue |
| A | PX4398 |
| site_id | HC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 373 |
| Chain | Residue |
| A | PX4371 |
| A | PX4401 |
| A | PX4406 |
| A | PX4410 |
| A | PX4414 |
| A | PX4426 |
| site_id | IC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 374 |
| Chain | Residue |
| A | PX4338 |
| A | PX4381 |
| A | PX4397 |
| A | PX4423 |
| A | PX4430 |
| site_id | IC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PX4 A 375 |
| Chain | Residue |
| A | PX4321 |
| A | PX4392 |
| A | PX4396 |
| A | PX4400 |
| A | PX4405 |
| A | PX4407 |
| A | PX4427 |
| site_id | IC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 376 |
| Chain | Residue |
| A | PX4359 |
| A | PX4390 |
| A | PX4396 |
| A | PX4407 |
| site_id | IC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 377 |
| Chain | Residue |
| A | PX4311 |
| A | PX4391 |
| A | PX4408 |
| A | C3S436 |
| site_id | IC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 378 |
| Chain | Residue |
| A | PX4366 |
| A | PX4388 |
| A | PX4408 |
| A | PX4414 |
| A | PX4426 |
| site_id | IC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 379 |
| Chain | Residue |
| A | PX4412 |
| A | PX4413 |
| A | PX4425 |
| A | PX4428 |
| site_id | IC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PX4 A 380 |
| Chain | Residue |
| A | PX4413 |
| site_id | IC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 381 |
| Chain | Residue |
| A | PX4370 |
| A | PX4374 |
| A | PX4402 |
| A | PX4417 |
| A | PX4418 |
| A | PX4423 |
| site_id | IC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 382 |
| Chain | Residue |
| A | PX4325 |
| A | PX4397 |
| A | PX4398 |
| A | PX4404 |
| A | PX4423 |
| A | C3S435 |
| site_id | JC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PX4 A 383 |
| Chain | Residue |
| A | PX4345 |
| A | PX4358 |
| A | PX4365 |
| A | PX4369 |
| A | PX4370 |
| A | PX4394 |
| A | PX4395 |
| A | PX4400 |
| A | PX4405 |
| A | PX4407 |
| site_id | JC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 384 |
| Chain | Residue |
| A | PX4392 |
| A | PX4399 |
| A | PX4400 |
| A | PX4405 |
| A | PX4427 |
| site_id | JC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PX4 A 385 |
| Chain | Residue |
| A | PX4398 |
| A | PX4415 |
| A | C3S433 |
| site_id | JC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 386 |
| Chain | Residue |
| A | PX4366 |
| A | PX4402 |
| A | PX4403 |
| A | PX4417 |
| A | PX4421 |
| site_id | JC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 387 |
| Chain | Residue |
| A | PX4404 |
| A | PX4415 |
| A | PX4416 |
| A | PX4421 |
| A | C3S433 |
| site_id | JC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 388 |
| Chain | Residue |
| A | PX4312 |
| A | PX4324 |
| A | PX4378 |
| A | PX4391 |
| A | PX4414 |
| site_id | JC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 389 |
| Chain | Residue |
| A | PX4333 |
| A | PX4399 |
| A | PX4401 |
| A | C3S434 |
| site_id | JC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PX4 A 390 |
| Chain | Residue |
| A | PX4365 |
| A | PX4376 |
| A | PX4393 |
| site_id | JC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 391 |
| Chain | Residue |
| A | PX4368 |
| A | PX4377 |
| A | PX4388 |
| A | PX4408 |
| A | C3S436 |
| site_id | KC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PX4 A 392 |
| Chain | Residue |
| A | PX4375 |
| A | PX4384 |
| A | PX4427 |
| site_id | KC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 393 |
| Chain | Residue |
| A | PX4351 |
| A | PX4365 |
| A | PX4390 |
| A | PX4413 |
| A | PX4419 |
| A | PX4429 |
| site_id | KC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 394 |
| Chain | Residue |
| A | PX4327 |
| A | PX4370 |
| A | PX4383 |
| A | PX4402 |
| A | PX4405 |
| A | PX4430 |
| site_id | KC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 395 |
| Chain | Residue |
| A | PX4371 |
| A | PX4383 |
| A | PX4401 |
| A | PX4402 |
| site_id | KC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 396 |
| Chain | Residue |
| A | PX4316 |
| A | PX4345 |
| A | PX4365 |
| A | PX4375 |
| A | PX4376 |
| A | PX4407 |
| site_id | KC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 397 |
| Chain | Residue |
| A | PX4374 |
| A | PX4382 |
| A | PX4398 |
| A | PX4411 |
| A | PX4423 |
| A | PX4430 |
| site_id | KC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 398 |
| Chain | Residue |
| A | PX4322 |
| A | PX4372 |
| A | PX4382 |
| A | PX4385 |
| A | PX4397 |
| A | C3S435 |
| site_id | KC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 399 |
| Chain | Residue |
| A | PX4384 |
| A | PX4389 |
| A | PX4401 |
| A | PX4410 |
| A | PX4424 |
| site_id | KC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 400 |
| Chain | Residue |
| A | PX4375 |
| A | PX4383 |
| A | PX4384 |
| A | PX4401 |
| A | PX4405 |
| site_id | LC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 401 |
| Chain | Residue |
| A | PX4373 |
| A | PX4389 |
| A | PX4395 |
| A | PX4399 |
| A | PX4400 |
| A | PX4405 |
| site_id | LC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 402 |
| Chain | Residue |
| A | PX4371 |
| A | PX4381 |
| A | PX4386 |
| A | PX4394 |
| A | PX4395 |
| site_id | LC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 403 |
| Chain | Residue |
| A | PX4349 |
| A | PX4366 |
| A | PX4386 |
| A | PX4417 |
| A | PX4421 |
| site_id | LC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 404 |
| Chain | Residue |
| A | PX4382 |
| A | PX4387 |
| A | PX4415 |
| A | PX4418 |
| A | PX4423 |
| site_id | LC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PX4 A 405 |
| Chain | Residue |
| A | PX4375 |
| A | PX4383 |
| A | PX4384 |
| A | PX4394 |
| A | PX4400 |
| A | PX4401 |
| A | PX4407 |
| A | PX4427 |
| site_id | LC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 406 |
| Chain | Residue |
| A | PX4368 |
| A | PX4373 |
| A | PX4410 |
| A | PX4414 |
| A | PX4426 |
| A | C3S436 |
| site_id | LC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PX4 A 407 |
| Chain | Residue |
| A | PX4348 |
| A | PX4359 |
| A | PX4375 |
| A | PX4376 |
| A | PX4383 |
| A | PX4396 |
| A | PX4405 |
| site_id | LC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 408 |
| Chain | Residue |
| A | PX4368 |
| A | PX4377 |
| A | PX4378 |
| A | PX4391 |
| A | C3S436 |
| site_id | LC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 410 |
| Chain | Residue |
| A | PX4373 |
| A | PX4399 |
| A | PX4406 |
| A | PX4424 |
| site_id | MC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PX4 A 411 |
| Chain | Residue |
| A | PX4397 |
| A | PX4412 |
| site_id | MC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 412 |
| Chain | Residue |
| A | PX4367 |
| A | PX4379 |
| A | PX4411 |
| A | PX4428 |
| site_id | MC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PX4 A 413 |
| Chain | Residue |
| A | PX4379 |
| A | PX4380 |
| A | PX4393 |
| A | PX4419 |
| A | PX4425 |
| A | PX4428 |
| A | PX4429 |
| site_id | MC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PX4 A 414 |
| Chain | Residue |
| A | PX4310 |
| A | PX4324 |
| A | PX4368 |
| A | PX4373 |
| A | PX4378 |
| A | PX4388 |
| A | PX4406 |
| A | PX4424 |
| A | PX4426 |
| A | C3S436 |
| site_id | MC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 415 |
| Chain | Residue |
| A | PX4313 |
| A | PX4385 |
| A | PX4387 |
| A | PX4404 |
| A | PX4421 |
| A | C3S433 |
| site_id | MC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PX4 A 416 |
| Chain | Residue |
| A | PX4387 |
| A | PX4421 |
| site_id | MC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 417 |
| Chain | Residue |
| A | PX4334 |
| A | PX4381 |
| A | PX4386 |
| A | PX4403 |
| A | PX4418 |
| A | PX4421 |
| site_id | MC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 418 |
| Chain | Residue |
| A | PX4320 |
| A | PX4381 |
| A | PX4404 |
| A | PX4417 |
| A | PX4421 |
| A | PX4423 |
| site_id | MC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 419 |
| Chain | Residue |
| A | PX4365 |
| A | PX4393 |
| A | PX4413 |
| A | PX4429 |
| site_id | NC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PX4 A 421 |
| Chain | Residue |
| A | PX4386 |
| A | PX4387 |
| A | PX4403 |
| A | PX4415 |
| A | PX4416 |
| A | PX4417 |
| A | PX4418 |
| site_id | NC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PX4 A 423 |
| Chain | Residue |
| A | PX4307 |
| A | PX4374 |
| A | PX4381 |
| A | PX4382 |
| A | PX4397 |
| A | PX4404 |
| A | PX4418 |
| site_id | NC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PX4 A 424 |
| Chain | Residue |
| A | PX4399 |
| A | PX4410 |
| A | PX4414 |
| site_id | NC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PX4 A 425 |
| Chain | Residue |
| A | PX4379 |
| A | PX4413 |
| site_id | NC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PX4 A 426 |
| Chain | Residue |
| A | PX4371 |
| A | PX4373 |
| A | PX4378 |
| A | PX4406 |
| A | PX4414 |
| A | C3S432 |
| site_id | NC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 427 |
| Chain | Residue |
| A | PX4375 |
| A | PX4384 |
| A | PX4392 |
| A | PX4405 |
| site_id | NC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 428 |
| Chain | Residue |
| A | PX4379 |
| A | PX4412 |
| A | PX4413 |
| A | PX4429 |
| site_id | NC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PX4 A 429 |
| Chain | Residue |
| A | PX4393 |
| A | PX4413 |
| A | PX4419 |
| A | PX4428 |
| site_id | NC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PX4 A 430 |
| Chain | Residue |
| A | PX4369 |
| A | PX4370 |
| A | PX4374 |
| A | PX4394 |
| A | PX4397 |
| site_id | OC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE C3S A 431 |
| Chain | Residue |
| A | PX4305 |
| A | PX4324 |
| A | PX4334 |
| A | PX4346 |
| site_id | OC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE C3S A 432 |
| Chain | Residue |
| A | TYR96 |
| A | PRO101 |
| A | HIS102 |
| A | PX4305 |
| A | PX4333 |
| A | PX4334 |
| A | PX4340 |
| A | PX4426 |
| site_id | OC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE C3S A 433 |
| Chain | Residue |
| A | PX4385 |
| A | PX4387 |
| A | PX4415 |
| site_id | OC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE C3S A 434 |
| Chain | Residue |
| A | PX4389 |
| site_id | OC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE C3S A 435 |
| Chain | Residue |
| A | PX4382 |
| A | PX4398 |
| site_id | OC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE C3S A 436 |
| Chain | Residue |
| A | PX4334 |
| A | PX4368 |
| A | PX4377 |
| A | PX4391 |
| A | PX4406 |
| A | PX4408 |
| A | PX4414 |
Functional Information from PROSITE/UniProt
| site_id | PS00546 |
| Number of Residues | 8 |
| Details | CYSTEINE_SWITCH Matrixins cysteine switch. PRCGvPDV |
| Chain | Residue | Details |
| A | PRO65-VAL72 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | ALA195 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: in inhibited form => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS67 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 17 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP133 | |
| A | GLY167 | |
| A | ASP169 | |
| A | HIS171 | |
| A | ASP173 | |
| A | GLU176 | |
| A | HIS194 | |
| A | HIS198 | |
| A | HIS204 | |
| A | HIS143 | |
| A | ASP145 | |
| A | ASP150 | |
| A | GLY151 | |
| A | GLY153 | |
| A | THR155 | |
| A | HIS158 | |
| A | GLY165 |
