2LV9

Solution NMR structure of the PHD domain of human MLL5, Northeast structural genomics consortium target HR6512A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Histone-lysine N-methyltransferase MLL5	polymer	98	11518.9	1	UniProt (Q8IZD2) Pfam (PF20826) In PDB	Homo sapiens (human)	Lysine N-methyltransferase 2E, KMT2E, Myeloid/lymphoid or mixed-lineage leukemia protein 5
2	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

A: 109 - 188 (UniProt: Q8IZD2)

PDB	External Database	Details
Met 91	-	expression tag
His 92	-	expression tag
His 93	-	expression tag
His 94	-	expression tag
His 95	-	expression tag
His 96	-	expression tag
His 97	-	expression tag
Ser 98	-	expression tag
Ser 99	-	expression tag
Gly 100	-	expression tag
Arg 101	-	expression tag
Glu 102	-	expression tag
Asn 103	-	expression tag
Leu 104	-	expression tag
Tyr 105	-	expression tag
Phe 106	-	expression tag
Gln 107	-	expression tag
Gly 108	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	11518.9
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	11649.7

*Water molecules are not included.