2LV9

Solution NMR structure of the PHD domain of human MLL5, Northeast structural genomics consortium target HR6512A

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 201

Chain	Residue
A	CYS121
A	CYS123
A	HIS143
A	CYS146
A	GLN177

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 202

Chain	Residue
A	CYS135
A	CYS138
A	CYS160
A	CYS163

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Functional Information from PROSITE/UniProt

site_id	PS01359
Number of Residues	43
Details	ZF_PHD_1 Zinc finger PHD-type signature. Ci.Cgfthddgym....................................IcCdk..Csvw.QHidCmgidrqhipdt..................................YlCerC

Chain	Residue	Details
A	CYS121-CYS163

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	ZN_FING: PHD-type => ECO:0000255|PROSITE-ProRule:PRU00146

Chain	Residue	Details
A	VAL118-ARG166

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829, ECO:0007744|PDB:2LV9, ECO:0007744|PDB:4L58

Chain	Residue	Details
A	CYS121
A	CYS123
A	CYS135
A	CYS138
A	HIS143
A	CYS146
A	CYS160
A	CYS163

---