2LP8

SOLUTION STRUCTURE OF AN APOPTOSIS ACTIVATING PHOTOSWITCHABLE BAK PEPTIDE BOUND to BCL-XL

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Bcl-2-like protein 1	polymer	185	21455.5	1	UniProt (Q07817) Pfam (PF02180) Pfam (PF00452)	Homo sapiens (human)	Bcl2-L-1, Apoptosis regulator Bcl-X
2	B (B)	Bcl-2 homologous antagonist/killer	polymer	18	1648.9	1	UniProt (Q16611)	Homo sapiens	Apoptosis regulator BAK, Bcl-2-like protein 7, Bcl2-L-7
3	C (B)	3,3'-(E)-diazene-1,2-diylbis{6-[(chloroacetyl)amino]benzenesulfonic acid}	non-polymer		525.3	1	Chemie (33B)

Sequence modifications

A: 1 - 44 (UniProt: Q07817)
A: 45 - 169 (UniProt: Q07817)

PDB	External Database	Details
Leu 170	-	expression tag
Glu 171	-	expression tag
His 172	-	expression tag
His 173	-	expression tag
His 174	-	expression tag
His 175	-	expression tag
His 176	-	expression tag
His 177	-	expression tag
Leu 178	-	expression tag
Glu 179	-	expression tag
His 180	-	expression tag
His 181	-	expression tag
His 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag

B: 1002 - 1017 (UniProt: Q16611)

PDB	External Database	Details
Ace 1001	-	acetylation
Cys 1003	Gln 73	engineered mutation
Ala 1007	Gln 77	engineered mutation
Ala 1010	Ile 80	engineered mutation
Phe 1011	Ile 81	engineered mutation
Cys 1014	Asp 84	engineered mutation
Nh2 1018	-	amidation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	23104.5
Non-Polymers*	Number of molecules	1
	Total formula weight	525.3
All*	Total formula weight	23629.8

*Water molecules are not included.