2LEC

Solution structure of human SRSF2 (SC35) RRM in complex with 5'-UGGAGU-3'

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Serine/arginine-rich splicing factor 2	polymer	135	15258.1	1	UniProt (Q01130) Pfam (PF00076)	Homo sapiens (human)	Protein PR264,Splicing component,35 kDa,Splicing factor SC35,SC-35,Splicing factor,arginine/serine-rich 2
2	B (B)	RNA (5'-R(*UP*GP*GP*AP*GP*U)-3')	polymer	6	1932.2	1		Synthetic construct

Sequence modifications

A: 1 - 101 (UniProt: Q01130)

PDB	External Database	Details
Met -33	-	initiating methionine
Gly -32	-	expression tag
Ser -31	-	expression tag
Ser -30	-	expression tag
His -29	-	expression tag
His -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
Ser -23	-	expression tag
Ser -22	-	expression tag
Gly -21	-	expression tag
Leu -20	-	expression tag
Val -19	-	expression tag
Pro -18	-	expression tag
Arg -17	-	expression tag
Gly -16	-	expression tag
Ser -15	-	expression tag
His -14	-	expression tag
Met -13	-	expression tag
Ala -12	-	expression tag
Ser -11	-	expression tag
Met -10	-	expression tag
Thr -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Gln -6	-	expression tag
Gln -5	-	expression tag
Met -4	-	expression tag
Gly -3	-	expression tag
Arg -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	17190.3
All*	Total formula weight	17190.3

*Water molecules are not included.