2KYG

Structure of the AML1-ETO Nervy Domain - PKA(RIIa) complex and its contribution to AML1-ETO activity

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	cAMP-dependent protein kinase type II-alpha regulatory subunit	polymer	50	5621.4	2	UniProt (P13861) Pfam (PF02197) In PDB	Homo sapiens (human)
2	C	Protein CBFA2T1	polymer	38	4184.7	1	UniProt (Q06455) In PDB	Homo sapiens (human)	Protein MTG8, Protein ETO, Eight twenty one protein, Cyclin-D-related protein, Zinc finger MYND domain-containing protein 2

Sequence modifications

A, B: -2 - 44 (UniProt: P13861)

PDB	External Database	Details
Gly -7	-	expression tag
Ala -6	-	expression tag
Met -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag

C: 585 - 615 (UniProt: Q06455)

PDB	External Database	Details
Ala 578	-	expression tag
Met 579	-	expression tag
Ala 580	-	expression tag
Asp 581	-	expression tag
Ile 582	-	expression tag
Gly 583	-	expression tag
Ser 584	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	15427.6
All*	Total formula weight	15427.6

*Water molecules are not included.