2JIU
Crystal structure of EGFR kinase domain T790M mutation in complex with AEE788
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | EPIDERMAL GROWTH FACTOR RECEPTOR | polymer | 328 | 37421.3 | 2 | UniProt (P00533) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1 |
| 2 | A | 6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE | non-polymer | 440.6 | 1 | Chemie (AEE) | |||
| 3 | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
A, B: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Met 790 | Thr 790 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74842.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 440.6 | |
| All* | Total formula weight | 75283.2 |
