2JFK

Structure of the MAT domain of human FAS with malonyl-CoA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	FATTY ACID SYNTHASE	polymer	433	47645.7	4	UniProt (P49327) Pfam (PF16197) Pfam (PF00698)	HOMO SAPIENS (HUMAN)
2	E, F, G, H (A, B, C, D)	COENZYME A	non-polymer		767.5	4	Chemie (COA)
3	I, J, K, L (A, B, C, D)	water	water		18.0	38	Chemie (HOH)

Sequence modifications

A, B, C, D: 422 - 831 (UniProt: P49327)

PDB	External Database	Details
Met 399	-	expression tag
His 400	-	expression tag
His 401	-	expression tag
His 402	-	expression tag
His 403	-	expression tag
His 404	-	expression tag
His 405	-	expression tag
Ser 406	-	expression tag
Ser 407	-	expression tag
Gly 408	-	expression tag
Val 409	-	expression tag
Asp 410	-	expression tag
Leu 411	-	expression tag
Gly 412	-	expression tag
Thr 413	-	expression tag
Glu 414	-	expression tag
Asn 415	-	expression tag
Leu 416	-	expression tag
Tyr 417	-	expression tag
Phe 418	-	expression tag
Gln 419	-	expression tag
Ser 420	-	expression tag
Met 421	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	190582.9
Non-Polymers*	Number of molecules	4
	Total formula weight	3070.1
All*	Total formula weight	193653.0

*Water molecules are not included.