2JC0
CRYSTAL STRUCTURE OF HEPATITIS C VIRUS POLYMERASE IN COMPLEX WITH INHIBITOR SB655264
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | RNA-DEPENDENT RNA-POLYMERASE | polymer | 570 | 63332.7 | 2 | UniProt (O39930) Pfam (PF00998) UniProt (by SIFTS) (P26663) In PDB | HEPATITIS C VIRUS | HEPATITIS C VIRUS RNA POLYMERASE |
| 2 | A, B | (2S,4S,5R)-2-ISOBUTYL-5-(2-THIENYL)-1-[4-(TRIFLUOROMETHYL)BENZOYL]PYRROLIDINE-2,4-DICARBOXYLIC ACID | non-polymer | 469.5 | 4 | Chemie (699) | |||
| 3 | water | water | 18.0 | 639 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 570 (UniProt: O39930)
| PDB | External Database | Details |
|---|---|---|
| His 120 | Arg 120 | conflict |
| Val 131 | Glu 131 | conflict |
| Val 185 | Ala 185 | conflict |
| Asn 213 | Cys 213 | conflict |
| Lys 254 | Arg 254 | conflict |
| Asn 316 | Cys 316 | conflict |
| Val 329 | Thr 329 | conflict |
| Val 338 | Ala 338 | conflict |
| Glu 464 | Gln 464 | conflict |
| Lys 531 | Arg 531 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 126665.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1877.9 | |
| All* | Total formula weight | 128543.2 |
