2J2I
Crystal Structure of the humab PIM1 in complex with LY333531
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1 | polymer | 312 | 35503.4 | 1 | UniProt (P11309) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | HUMAN PIM1 |
| 2 | B (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | C (B) | (9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIA ZACYCLOHEXADECINE-18,20-DIONE | non-polymer | 468.5 | 1 | Chemie (LY4) | |||
| 4 | D (B) | water | water | 18.0 | 168 | Chemie (HOH) |
Sequence modifications
B: 1 - 312 (UniProt: P11309)
| PDB | External Database | Details |
|---|---|---|
| Gly 250 | Arg 341 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35503.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 564.6 | |
| All* | Total formula weight | 36068.0 |
