Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2J2I

Crystal Structure of the humab PIM1 in complex with LY333531

Functional Information from GO Data
ChainGOidnamespacecontents
B0000166molecular_functionnucleotide binding
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006468biological_processprotein phosphorylation
B0006915biological_processapoptotic process
B0007049biological_processcell cycle
B0008134molecular_functiontranscription factor binding
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016740molecular_functiontransferase activity
B0022898biological_processregulation of transmembrane transporter activity
B0030145molecular_functionmanganese ion binding
B0043024molecular_functionribosomal small subunit binding
B0043066biological_processnegative regulation of apoptotic process
B0043433biological_processnegative regulation of DNA-binding transcription factor activity
B0045824biological_processnegative regulation of innate immune response
B0045893biological_processpositive regulation of DNA-templated transcription
B0046777biological_processprotein autophosphorylation
B0046872molecular_functionmetal ion binding
B0050821biological_processprotein stabilization
B0060045biological_processpositive regulation of cardiac muscle cell proliferation
B0070561biological_processvitamin D receptor signaling pathway
B0071346biological_processcellular response to type II interferon
B0090336biological_processpositive regulation of brown fat cell differentiation
B0106310molecular_functionprotein serine kinase activity
B1902033biological_processregulation of hematopoietic stem cell proliferation
B1904263biological_processpositive regulation of TORC1 signaling
B1905062biological_processpositive regulation of cardioblast proliferation
B1990748biological_processcellular detoxification
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 1306
ChainResidue
BARG156
BARG258
BSER261
BPHE281
BHOH2166
BHOH2167
BHOH2168

site_idAC2
Number of Residues19
DetailsBINDING SITE FOR RESIDUE LY4 B 1307
ChainResidue
BPHE49
BVAL52
BALA65
BLYS67
BGLU89
BILE104
BLEU120
BGLU121
BARG122
BPRO123
BVAL126
BASP128
BGLU171
BASN172
BLEU174
BILE185
BASP186
BLEU44
BGLY45

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGGFGSVYsGirvsdnlp..........VAIK
ChainResidueDetails
BLEU44-LYS67

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDIKdeNILI
ChainResidueDetails
BVAL163-ILE175

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
BASP76

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862
ChainResidueDetails
BGLU30
BGLN37

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:15657054
ChainResidueDetails
BASN7
BASP170

218853

PDB entries from 2024-04-24

PDB statisticsPDBj update infoContact PDBjnumon