2J0F
Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | THYMIDINE PHOSPHORYLASE | polymer | 482 | 50030.4 | 4 | UniProt (P19971) Pfam (PF02885) Pfam (PF00591) Pfam (PF07831) In PDB | HOMO SAPIENS (HUMAN) | TDRPASE, TP, PLATELET-DERIVED ENDOTHELIAL CELL GROWTH FACTOR, GLIOSTATIN, PD-ECGF |
| 2 | A, B, C | THYMINE | non-polymer | 126.1 | 3 | Chemie (TDR) | |||
| 3 | water | water | 18.0 | 450 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 482 (UniProt: P19971)
| PDB | External Database | Details |
|---|---|---|
| Ala 238 | Gly 238 | conflict |
| Gly 239 | Ala 239 | conflict |
| Leu 471 | Ser 471 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 200121.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 378.3 | |
| All* | Total formula weight | 200499.9 |
