2ITN
Crystal structure of EGFR kinase domain G719S mutation in complex with AMP-PNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | EPIDERMAL GROWTH FACTOR RECEPTOR | polymer | 327 | 37334.2 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | HOMO SAPIENS | RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1 |
| 2 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | A | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 4 | water | water | 18.0 | 153 | Chemie (HOH) |
Sequence modifications
A: 696 - 1019 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Ser 719 | Gly 719 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37334.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 530.5 | |
| All* | Total formula weight | 37864.7 |
