2IO2

Crystal structure of human Senp2 in complex with RanGAP1-SUMO-1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Sentrin-specific protease 2	polymer	232	27342.6	1	UniProt (Q9HC62) Pfam (PF02902) In PDB	Homo sapiens (human)	Sentrin/SUMO-specific protease SENP2, SMT3-specific isopeptidase 2, Smt3ip2, Axam2
2	B	Small ubiquitin-related modifier 1	polymer	82	9473.8	1	UniProt (P63165) Pfam (PF11976) In PDB	Homo sapiens (human)	SUMO-1, Ubiquitin-like protein SMT3C, SMT3 homolog 3, Ubiquitin-homology domain protein PIC1, Ubiquitin-like protein UBL1, GAP-modifying protein 1, GMP1, Sentrin
3	C	Ran GTPase-activating protein 1	polymer	172	18670.5	1	UniProt (P46060) Pfam (PF07834) In PDB	Homo sapiens (human)
4		water	water		18.0	8	Chemie (HOH)

Sequence modifications

A: 364 - 589 (UniProt: Q9HC62)

PDB	External Database	Details
Gly 358	-	cloning artifact
Ser 359	-	cloning artifact
His 360	-	cloning artifact
Met 361	-	cloning artifact
Ala 362	-	cloning artifact
Ser 363	-	cloning artifact
Ser 548	Cys 548	engineered mutation

B: 18 - 97 (UniProt: P63165)

PDB	External Database	Details
Met 16	-	cloning artifact
Gly 17	-	cloning artifact

C: 418 - 587 (UniProt: P46060)

PDB	External Database	Details
Ser 416	-	cloning artifact
Leu 417	-	cloning artifact
Ser 573	Cys 573	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	55487.0
All*	Total formula weight	55487.0

*Water molecules are not included.