2IO0
Crystal structure of human Senp2 in complex with preSUMO-2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Sentrin-specific protease 2 | polymer | 232 | 27342.6 | 1 | UniProt (Q9HC62) Pfam (PF02902) In PDB | Homo sapiens (human) | Sentrin/SUMO-specific protease SENP2, SMT3-specific isopeptidase 2, Smt3ip2, Axam2 |
| 2 | B | Small ubiquitin-related modifier 2 precursor | polymer | 91 | 10598.9 | 1 | UniProt (P61956) Pfam (PF11976) In PDB | Homo sapiens (human) | SUMO-2, Ubiquitin-like protein SMT3B, SMT3 homolog 2, Sentrin-2, HSMT3 |
| 3 | A, B | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
A: 364 - 589 (UniProt: Q9HC62)
B: 15 - 95 (UniProt: P61956)
| PDB | External Database | Details |
|---|---|---|
| Gly 358 | - | cloning artifact |
| Ser 359 | - | cloning artifact |
| His 360 | - | cloning artifact |
| Met 361 | - | cloning artifact |
| Ala 362 | - | cloning artifact |
| Ser 363 | - | cloning artifact |
| Ser 548 | Cys 548 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 13 | - | cloning artifact |
| Ala 14 | - | cloning artifact |
| Leu 96 | - | cloning artifact |
| Glu 97 | - | cloning artifact |
| His 98 | - | cloning artifact |
| His 99 | - | cloning artifact |
| His 100 | - | cloning artifact |
| His 101 | - | cloning artifact |
| His 102 | - | cloning artifact |
| His 103 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 37941.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 288.2 | |
| All* | Total formula weight | 38229.7 |
