2IJO
Crystal Structure of the West Nile virus NS2B-NS3 protease complexed with bovine pancreatic trypsin inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Polyprotein | polymer | 58 | 6078.4 | 1 | UniProt (Q203W3) Pfam (PF01002) UniProt (by SIFTS) (P06935) In PDB | West Nile virus | NON-STRUCTURAL PROTEIN 2B, NS2B |
| 2 | B | Polyprotein | polymer | 192 | 20906.6 | 1 | UniProt (Q203W3) Pfam (PF00949) UniProt (by SIFTS) (P06935) In PDB | West Nile virus | NON-STRUCTURAL PROTEIN 3, NS3 |
| 3 | I | Pancreatic trypsin inhibitor | polymer | 58 | 6527.6 | 1 | UniProt (P00974) Pfam (PF00014) In PDB | Bos taurus (cattle) | Basic protease inhibitor, BPI, BPTI, Aprotinin |
| 4 | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A: 49 - 95 (UniProt: Q203W3)
B: 1 - 184 (UniProt: Q203W3)
| PDB | External Database | Details |
|---|---|---|
| Met 48 | - | initiating methionine |
| Ala 96 | - | SEE REMARK 999 |
| Gly 97 | - | SEE REMARK 999 |
| Gly 98 | - | SEE REMARK 999 |
| Gly 99 | - | SEE REMARK 999 |
| Gly 100 | - | SEE REMARK 999 |
| Ser 101 | - | SEE REMARK 999 |
| Gly 102 | - | SEE REMARK 999 |
| Gly 103 | - | SEE REMARK 999 |
| Gly 104 | - | SEE REMARK 999 |
| Gly 105 | - | SEE REMARK 999 |
| PDB | External Database | Details |
|---|---|---|
| Gln 84 | Lys 1589 | variant |
| Arg 104 | Lys 1609 | engineered mutation |
| Lys 185 | - | cloning artifact |
| Gly 186 | - | cloning artifact |
| His 187 | - | cloning artifact |
| His 188 | - | cloning artifact |
| His 189 | - | cloning artifact |
| His 190 | - | cloning artifact |
| His 191 | - | cloning artifact |
| His 192 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 33512.6 | |
| All* | Total formula weight | 33512.6 |
