2IJD

Crystal Structure of the Poliovirus Precursor Protein 3CD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	1, 2	Picornain 3C, RNA-directed RNA polymerase	polymer	644	72009.1	2	UniProt (P03300) Pfam (PF00548) Pfam (PF00680) UniProt (by SIFTS) (Q1PHW8) In PDB	Human poliovirus 1	Protease 3C, P3C, RNA-directed RNA polymerase, P3D, 3CD
2	1, 2	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	1, 2	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
4		water	water		18.0	8	Chemie (HOH)

Sequence modifications

1, 2: 1 - 644 (UniProt: P03300)

PDB	External Database	Details
Ala 55	Glu 1619	engineered mutation
Ala 58	Asp 1622	engineered mutation
Ala 63	Glu 1627	engineered mutation
Ala 147	Cys 1711	engineered mutation
Asp 629	Leu 2193	engineered mutation
Asp 638	Arg 2202	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	144018.2
Non-Polymers*	Number of molecules	10
	Total formula weight	899.3
All*	Total formula weight	144917.5

*Water molecules are not included.